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Anti-HLA Class II DR4 Polyclonal Antibody
😃Good
Catalog No. TMAB-07149
Anti-HLA Class II DR4 Polyclonal Antibody is a Rabbit antibody targeting HLA Class II DR4. Anti-HLA Class II DR4 Polyclonal Antibody can be used in WB.
Anti-HLA Class II DR4 Polyclonal Antibody
Anti-HLA Class II DR4 Polyclonal Antibody
😃Good
Catalog No. TMAB-07149
Anti-HLA Class II DR4 Polyclonal Antibody is a Rabbit antibody targeting HLA Class II DR4. Anti-HLA Class II DR4 Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-HLA Class II DR4 Polyclonal Antibody is a Rabbit antibody targeting HLA Class II DR4. Anti-HLA Class II DR4 Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Monkey) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane 3 Publications; Single-pass type I membrane protein. Endoplasmic reticulum membrane 1 Publication; Single-pass type I membrane protein. Lysosome membrane 2 Publications; Single-pass type I membrane protein. Late endosome membrane 2 Publications; Single-pass type I membrane protein. Autolysosome membrane. |
| Tissue Specificity | Expressed in professional APCs: monocyte/macrophages, dendritic cells and B cells (at protein level)Expressed in thymic epithelial cells (at protein level) |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene. [provided by RefSeq, Jul 2020] |
| Immunogen | KLH conjugated synthetic peptide: human HLA Class II DR4 |
| Antigen Species | Human |
| Gene Name | HLA-DRB1 |
| Gene ID | |
| Protein Name | HLA class II histocompatibility antigen, DRB1 beta chain |
| Function | A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells |
| Molecular Weight | Theoretical: 26 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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