This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
VEGFR-2/DHFR-IN-1
Catalog No. T61489
VEGFR-2/DHFR-IN-1 (compound 8b) is a chemical inhibitor targeting VEGFR-2 and DHFR, exhibiting IC50 values of 0.384 μM and 7.881 μM, respectively. It demonstrates effective antibacterial properties against a range of pathogens including Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA, and MRSA, with MIC values ranging from 8 to 16 μg/mL. Additionally, this compound shows potent cytotoxic effects against various cancer cell lines such as C26, HepG2, and MCF7, with IC50 values between 2.97 and 7.12 μM, rendering it a valuable tool for cancer research [1].
All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage
& Solubility Information
Description
VEGFR-2/DHFR-IN-1 (compound 8b) is a chemical inhibitor targeting VEGFR-2 and DHFR, exhibiting IC50 values of 0.384 μM and 7.881 μM, respectively. It demonstrates effective antibacterial properties against a range of pathogens including Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA, and MRSA, with MIC values ranging from 8 to 16 μg/mL. Additionally, this compound shows potent cytotoxic effects against various cancer cell lines such as C26, HepG2, and MCF7, with IC50 values between 2.97 and 7.12 μM, rendering it a valuable tool for cancer research [1].
In vitro
VEGFR-2/DHFR-IN-1, at concentrations ranging from 2-1024 μg/mL over 18-72 hours, demonstrates significant antimicrobial activity, as evidenced by minimum inhibitory concentration (MIC) values against a variety of pathogens: 16 μg/mL for Escherichia coli, 64 μg/mL for Pseudomonas aeruginosa, 16 μg/mL for Streptococcus faecalis, 16 μg/mL for Salmonella enterica, 8 μg/mL for MSSA, 16 μg/mL for MRSA, 64 μg/mL for Candida albicans, and 256 μg/mL for Aspergillus niger. Additionally, at 0.5-100 μM for 48 hours, it exhibits potent anticancer effects. Its inhibitory action on DHFR and VEGFR-2, identified through concentrations of 0-100 μM over 30 minutes, shows IC50s of 7.881 μM and 0.384 μM, respectively. Furthermore, cell cytotoxicity assays on C26, HepG2, MCF7, and H69PR cell lines, using concentrations between 0.5 and 100 μM over 48 hours, reveal VEGFR-2/DHFR-IN-1's anticancer capabilities, with IC50s of 2.97 μM for C26, 7.12 μM for HepG2, 3.58 μM for MCF7, and 12.79 μM for H69PR cells.
Molecular Weight
371.81
Formula
C20H18ClNO4
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dose Conversion
You can also refer to dose conversion for different animals.
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Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.