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N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline

🥰Excellent
Catalog No. T9837Cas No. 1352608-94-6

Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.

N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline

N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline

🥰Excellent
Purity: 99.935%
Catalog No. T9837Cas No. 1352608-94-6
Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.
Pack SizePriceAvailabilityQuantity
1 mg$89In Stock
5 mg$202In Stock
10 mg$298In Stock
25 mg$476In Stock
50 mg$678In Stock
100 mg$912In Stock
200 mg$1,220In Stock
1 mL x 10 mM (in DMSO)$238In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.935%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.
Targets&IC50
TGFβRI:7 nM
Chemical Properties
Molecular Weight460.33
FormulaC22H18BrN7
Cas No.1352608-94-6
SmilesC(NC1=C(Br)C=CC=C1)C=2NC(=C(N2)C=3N=C(C)C=CC3)C4=CN5C(C=C4)=NC=N5
Relative Density.1.56 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (108.62 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1724 mL10.8618 mL21.7235 mL108.6177 mL
5 mM0.4345 mL2.1724 mL4.3447 mL21.7235 mL
10 mM0.2172 mL1.0862 mL2.1724 mL10.8618 mL
20 mM0.1086 mL0.5431 mL1.0862 mL5.4309 mL
50 mM0.0434 mL0.2172 mL0.4345 mL2.1724 mL
100 mM0.0217 mL0.1086 mL0.2172 mL1.0862 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

N((4([1,2,4]triazolo[1,5a]pyridin6yl)5(6methylpyridin2yl)1Himidazol2yl)methyl)2bromoanilineN ((4 ([1,2,4]triazolo[1,5 a]pyridin 6 yl) 5 (6 methylpyridin 2 yl) 1H imidazol 2 yl)methyl) 2 bromoanilineALK5
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