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F5446
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Catalog No. T71890Cas No. 2304465-89-0
Alias F 5446
F5446 is a selective small molecule SUV39H1 methyltransferase inhibitor. It promotes apoptosis in colorectal cancer cells by inhibiting the deposition of H3K9me3 on the FAS promoter to increase Fas expression, while inhibiting CTL effector gene expression.
F5446
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Purity: 98.56%
Catalog No. T71890Alias F 5446Cas No. 2304465-89-0
F5446 is a selective small molecule SUV39H1 methyltransferase inhibitor. It promotes apoptosis in colorectal cancer cells by inhibiting the deposition of H3K9me3 on the FAS promoter to increase Fas expression, while inhibiting CTL effector gene expression.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $97 | - | In Stock | |
| 5 mg | $239 | - | In Stock | |
| 10 mg | $388 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $289 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.56%
Appearance:Solid
Color:Orange to Red
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Storage & Solubility Information
| Description | F5446 is a selective small molecule SUV39H1 methyltransferase inhibitor. It promotes apoptosis in colorectal cancer cells by inhibiting the deposition of H3K9me3 on the FAS promoter to increase Fas expression, while inhibiting CTL effector gene expression. |
| In vitro | Methods: SW620 and LS411N cells were treated with F5446 (100, 250 nM, 48 h), then fixed, stained with PI, and analyzed for DNA content by flow cytometry. Results: F5446 treatment induced cell cycle arrest at S phase in both SW620 and LS411N cells in a concentration-dependent manner. Methods: SW620, LS411N and CCD841 cells were treated with F5446 (10, 50, 100, 250, 500, 1000 nM) and analyzed for apoptosis. Results: F5446 induced apoptosis in both tumor cell lines in vitro in a concentration-dependent manner. The normal human colon epithelial cell line CCD841 was less sensitive to F5446 in inducing apoptotic cell death than tumor cells. [1] |
| In vivo | Methods: F5446 (5, 10 mg/kg, intraperitoneal injection, once every two days, for 26 days) was used to treat SW620 and SW620-5FUR cell-transplanted tumor model mice. Results: F5446 can inhibit tumor growth in vivo in a concentration-dependent manner. [1] |
| Synonyms | F 5446 |
| Molecular Weight | 552.94 |
| Formula | C26H17ClN2O8S |
| Cas No. | 2304465-89-0 |
| Smiles | COC(=O)c1cc2-c3c(c[nH]c3C(=O)C(=O)c2n1S(=O)(=O)c1ccc(Cl)cc1)C(=O)OCc1ccccc1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (144.68 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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