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Anti-Phospho-FOXO3 (S253) Antibody (7U72)

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Catalog No. TMAC-03216

Anti-Phospho-FOXO3 (S253) Antibody (7U72) is a Rabbit antibody targeting Phospho-FOXO3 (S253). Anti-Phospho-FOXO3 (S253) Antibody (7U72) can be used in WB,IHC.

Anti-Phospho-FOXO3 (S253) Antibody (7U72)

Anti-Phospho-FOXO3 (S253) Antibody (7U72)

😃Good
Catalog No. TMAC-03216
Anti-Phospho-FOXO3 (S253) Antibody (7U72) is a Rabbit antibody targeting Phospho-FOXO3 (S253). Anti-Phospho-FOXO3 (S253) Antibody (7U72) can be used in WB,IHC.
Pack SizePriceAvailabilityQuantity
50 μL$2987-10 days
100 μL$4967-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-FOXO3 (S253) Antibody (7U72) is a Rabbit antibody targeting Phospho-FOXO3 (S253). Anti-Phospho-FOXO3 (S253) Antibody (7U72) can be used in WB,IHC.
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1:1000-5000; IHC: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundFKHRL1 (for forkhead in rhabdomyosarcoma) is a member of the FKHR subfamily of forkhead transcription factors. Transcriptional activation of FKHR proteins is regulated by the serine/threonine kinase Akt1, which phosphorylates FKHRL1 at threonine-32 and serine-253. Phosphorylation by Akt1 negatively regulates FKHRL1 by promoting its export from the nucleus. Phosphorylated FKHRL1 associates with 14-3-3 proteins and this complex is retained in the cytoplasm. Growth factor withdrawal stimulates FKHRL1 dephosphorylation and nuclear translocation, leading to FKHR-induced gene-specific transcriptional activation. Within the nucleus, dephospho-rylated FKHRL1 triggers apoptosis by inducing the expression of genes that are critical for cell death.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
A synthesized phosphopeptide: human FOXO3a around the phosphorylation site of Ser253
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 71 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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