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Anti-Phospho-FOXO3 (S253) Antibody (7U72)
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Catalog No. TMAC-03216
Anti-Phospho-FOXO3 (S253) Antibody (7U72) is a Rabbit antibody targeting Phospho-FOXO3 (S253). Anti-Phospho-FOXO3 (S253) Antibody (7U72) can be used in WB,IHC.
Anti-Phospho-FOXO3 (S253) Antibody (7U72)
Anti-Phospho-FOXO3 (S253) Antibody (7U72)
😃Good
Catalog No. TMAC-03216
Anti-Phospho-FOXO3 (S253) Antibody (7U72) is a Rabbit antibody targeting Phospho-FOXO3 (S253). Anti-Phospho-FOXO3 (S253) Antibody (7U72) can be used in WB,IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $298 | 7-10 days | |
| 100 μL | $496 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-Phospho-FOXO3 (S253) Antibody (7U72) is a Rabbit antibody targeting Phospho-FOXO3 (S253). Anti-Phospho-FOXO3 (S253) Antibody (7U72) can be used in WB,IHC. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:1000-5000; IHC: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | FKHRL1 (for forkhead in rhabdomyosarcoma) is a member of the FKHR subfamily of forkhead transcription factors. Transcriptional activation of FKHR proteins is regulated by the serine/threonine kinase Akt1, which phosphorylates FKHRL1 at threonine-32 and serine-253. Phosphorylation by Akt1 negatively regulates FKHRL1 by promoting its export from the nucleus. Phosphorylated FKHRL1 associates with 14-3-3 proteins and this complex is retained in the cytoplasm. Growth factor withdrawal stimulates FKHRL1 dephosphorylation and nuclear translocation, leading to FKHR-induced gene-specific transcriptional activation. Within the nucleus, dephospho-rylated FKHRL1 triggers apoptosis by inducing the expression of genes that are critical for cell death. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | A synthesized phosphopeptide: human FOXO3a around the phosphorylation site of Ser253 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Theoretical: 71 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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