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GW406108X(Z/E)
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Catalog No. T9207LCas No. 265098-01-9
GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .
GW406108X(Z/E)
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Purity: 98.23%
Catalog No. T9207LCas No. 265098-01-9
GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $133 | In Stock | In Stock | |
| 5 mg | $302 | In Stock | In Stock | |
| 10 mg | $453 | In Stock | In Stock | |
| 25 mg | $680 | In Stock | In Stock | |
| 50 mg | $1,020 | In Stock | In Stock | |
| 100 mg | $1,370 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $297 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.23%
Appearance:Solid
Color:White
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Product Introduction
GW406108X(Z/E) AI Summary
GW406108X(Z/E) exhibits significant bioactivities, including the inhibition of cRaf1 kinase with an IC50 value of 46.0 nM and a 94.0% inhibition of EGF-stimulated MAP kinase activation at a concentration of 15 µM, without affecting EGFR phosphorylation. It also demonstrates moderate inhibition of IKK-alpha and IKK-beta and a high level of inhibition for IKK-epsilon at 1 µM concentration. Additionally, it shows strong inhibition of PIP5K1 at 5 µM concentration and considerable inhibition of TBK1 at 1 µM concentration. The compound exhibits variable effects on cell viability in different cell lines, suggesting cell-type-specific responses. In thermal shift assays, GW406108X(Z/E) significantly increases thermal stability for several protein domains (ΔTm values from 0.54°C to 5.93°C) but decreases stability (ΔTm = -3.45°C) for the G861-E979 domain, indicating potential binding and stabilization effects on these regions. The compound also inhibits Sea Pansy Luciferase with an AC50 of 16343.2 nM and Firefly Luciferase with an AC50 of 18337.4 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 . |
| Molecular Weight | 400.21 |
| Formula | C20H11Cl2NO4 |
| Cas No. | 265098-01-9 |
| Smiles | C(=C1C=2C(NC1=O)=CC=C(C(=O)C3=CC=CO3)C2)C4=CC(Cl)=C(O)C(Cl)=C4 |
| Relative Density. | 1.527 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (74.96 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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