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Anti-CYP1B1 Polyclonal Antibody
Catalog No. TMAB-04872 Copy Product Info
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Anti-CYP1B1 Polyclonal Antibody is a Rabbit antibody targeting CYP1B1. Anti-CYP1B1 Polyclonal Antibody can be used in WB.
Anti-CYP1B1 Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-04872
Anti-CYP1B1 Polyclonal Antibody is a Rabbit antibody targeting CYP1B1. Anti-CYP1B1 Polyclonal Antibody can be used in WB.
Anti-CYP1B1 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-CYP1B1 Polyclonal Antibody is a Rabbit antibody targeting CYP1B1. Anti-CYP1B1 Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Rat,Dog,Horse) |
| Verified Activity | Sample: Spleen (Mouse) Lysate at 40 μg Primary: Anti-CYP1B1 (TMAB-04872) at 1/300 dilution Secondary: HRP conjugated Goat-Anti-rabbit IgG at 1/5000 dilution Predicted band size: 61 kD Observed band size: 63 kD |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Endoplasmic reticulum membrane. Microsome membrane. |
| Tissue Specificity | Expressed in many tissues. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Cytochrome P450 1B1 is a key enzyme involved in the production of potentially carcinogenic estrogen metabolites and the activation of environmental carcinogens and is the predominant member of the CYP1 family expressed in normal breast tissue and breast cancer. Estrogen has been proposed to trigger breast cancer development via an initiating mechanism involving its metabolite, catechol estrogen (CE). CYP1B1 catalyzes the conversion of 17-beta-estradiol to the catechol estrogen metabolites 2-OH-E2 and 4-OH-E2 which have both been postulated to be involved in mammary carcinogenesis. Genetic polymorphisms in CYP1B1 may play an important role in human prostate carcinogenesis as well. Polymorphism of the CYP1B1 gene at codon 432 (Val-->Leu) is associated with a change in catalytic function. |
| Immunogen | KLH conjugated synthetic peptide: human CYP1B1 |
| Antigen Species | Human |
| Gene Name | CYP1B1 |
| Gene ID | |
| Protein Name | Cytochrome P450 1B1 |
| Uniprot ID | |
| Function | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Participates in the metabolism of an as-yet-unknown biologically active molecule that is a participant in eye development. |
| Molecular Weight | Theoretical: 61 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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