Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Arrestin

Arrestins (abbreviated Arr) are a small family of proteins important for regulating signal transduction at G protein-coupled receptors. Arrestins were first discovered as a part of a conserved two-step mechanism for regulating the activity of G protein-coupled receptors (GPCRs).

ELA-14(human) acetate
TP1923L1
ELA-14(human) acetate is a fragment of ELA that binds to APJ, activates the Gαi1 and β-arrestin-2 signaling pathways, and induces receptor internalization similarly to its parent endogenous peptide.
  • $34
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Barbadin
T14498356568-70-2
Barbadin is a novel and specific inhibitor of β-arrestin β2-adaptin interaction with an IC50 value of 19.1 μM for β-arestin1 and 15.6 μM for β-arestin2. Barbadin potentiates the long term effects of lorcaserin on POMC neurons and weight loss. Barbadin potentiates the long-term effects of lorcaserin on POMC neurons and weight loss, blocks agonist-promoted endocytosis of prototypic β2-adrenergic, V2-vasopressin, and angiotensin-II-1 receptors, and may be useful in the study of obesity.
  • $44
In Stock
Size
QTY
TRV-120027 acetate (1234510-46-3 free base)
TP2158L11824712-70-0
TRV-120027 acetate is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1 receptor) and engages -arrestins while blocking G-protein signaling.
  • $100
In Stock
Size
QTY
CCX777
T238661226686-36-7
CCX777 is a partial agonist recruited to ACKR3 by β-arrestin-2 and is used in cancer research.
  • $299
In Stock
Size
QTY
7-FluorotryptaMine HCl
T77673159730-09-3
7-FluorotryptaMine HCl is a potent aromatic monoamine GPRC5A agonist that induces GPRC5A-mediated β-arrestin recruitment.7-FluorotryptaMine HCl can be used to study signalling pathways related to immunity and cancer.
  • $37
In Stock
Size
QTY
TRV-120027 TFA
TP2158
TRV120027 TFA is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R) and engages ß-arrestins while blocking G-protein signaling.
  • $38
In Stock
Size
QTY
VUF11207 fumarate
T133241785665-61-3
VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).
  • $36
In Stock
Size
QTY
ML221
T4390877636-42-5
ML221 is a potent apelin /APJ functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.
  • $50
In Stock
Size
QTY
ML417
T84231386162-69-1
ML417 is a selective and brain-penetrant agonist of D3 dopamine (EC50: 38 nM).
  • $33
In Stock
Size
QTY
ML192
T33452460331-61-7
ML192 (CID1434953) is a selective GPR55 ligand antagonist. ML192 is an inhibitor that inhibits β-arrestin transport, ERK1/2 phosphorylation, and PKCβII translocation.
  • $30
In Stock
Size
QTY
GAT211
T27405102704-40-5
GAT211 (AZ-4) is a selective and potent cannabinoid 1 receptor (CB1R) orthosteric modulator (PAM) with high affinity for cAMP and β-arrestin2.GAT211 has IOP-lowering and antipsychotic effects and can be used in the study of epilepsy.
  • $30
In Stock
Size
QTY
GPR35 agonist 3
T72755123021-85-2In house
GPR35 agonist 3 is a synthetic GPR35 agonist with an EC50 value of 1.4 μg in the β-arrestin recruitment assay.GPR35 agonist 3 is used in the study of cancer, type 2 diabetes, and cardiovascular disease.
  • $42 TargetMol
In Stock
Size
QTY
ELA-11 (human) acetate(1784687-32-6 free base)
TP1922L1
ELA-11 (human) acetate high affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.
  • $133
In Stock
Size
QTY
TC14012 acetate
TP2112L
TC14012 acetate is a serum-stable derivative of T140 which is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is also a potent CXCR7 agonist with an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has anti-cancer activity and anti-HIV activity.
  • $77
In Stock
Size
QTY
DHICA
T2014994790-08-3
DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an intermediate in melanin synthesis and a component of eumelanin, as well as acting as a moderate potency agonist of GPR35. In the U2OS cell line, DHICA demonstrates the ability to induce β-arrestin translocation signaling with an EC50 value of 23.2 μM. Additionally, it plays a significant role in promoting and protecting against DNA damage.
  • Inquiry Price
10-14 weeks
Size
QTY
SCH-900875
T207741907206-98-8
SCH-900875 is an orally active, brain-penetrant, and selective inhibitor of the CXCR3 receptor, demonstrating significant selectivity towards CXCR1 and CXCR2 receptors as well. By binding to CXCR3, SCH-900875 blocks the ligands CXCL9, CXCL10, and CXCL11, thereby inhibiting downstream G protein and β-arrestin signaling pathways and reducing inflammation cell migration. This compound holds potential for research into autoimmune diseases (such as rheumatoid arthritis and multiple sclerosis) and inflammatory conditions (such as psoriasis and inflammatory bowel disease).
  • Inquiry Price
10-14 weeks
Size
QTY