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Arrestin

  • TRV-120027 acetate (1234510-46-3 free base)
    TP2158L11824712-70-0
    TRV-120027 acetate is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1 receptor) and engages -arrestins while blocking G-protein signaling.
    • $100
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  • ELA-14(human) acetate
    TP1923L1
    ELA-14(human) acetate is a fragment of ELA that binds to APJ, activates the Gαi1 and β-arrestin-2 signaling pathways, and induces receptor internalization similarly to its parent endogenous peptide.
    • $95
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  • ELA-11 (human) acetate(1784687-32-6 free base)
    TP1922L1
    ELA-11 (human) acetate high affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.
    • $133
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  • TC14012 acetate
    TP2112L
    TC14012 acetate is a serum-stable derivative of T140 which is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is also a potent CXCR7 agonist with an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has anti-cancer activity and anti-HIV activity.
    • $77
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  • GPR35 agonist 2
    T23434494191-73-0In house
    GPR35 agonist 2 (TC-G 1001) is a potent GPR35 agonist.The EC50 values of GPR35 agonist 2 in the β-arrestin and Ca2+ release assays were 26 and 3.2 nM, respectively.
    • $44
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  • GP 1a
    T41231511532-96-0In house
    GP 1a is a potent agonist of cannabinoid receptor 2 (CB2) (EC50=7.1), as shown in cAMP, GTPγS and β-arrestin recruitment assays. GP 1a is approximately 30-fold more selective for CB2 receptors than CB1 receptors and increases P-ERK1/2 expression in HL-60 cells in vitro. GP 1a is beneficial for skin wound healing. GP 1a inhibits inflammation and fibrogenesis while promoting epithelial re-formation.
    • $51
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    TargetMol | Inhibitor Sale
  • GPR35 agonist 3
    T72755123021-85-2
    GPR35 agonist 3 is a synthetic GPR35 agonist with an EC50 value of 1.4 μg in the β-arrestin recruitment assay.GPR35 agonist 3 is used in the study of cancer, type 2 diabetes, and cardiovascular disease.
    • $42 TargetMol
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    TargetMol | Inhibitor Sale
  • ML221
    T4390877636-42-5
    ML221 is a potent apelin APJ functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.
    • $50
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    TargetMol | Citations Cited
  • 7-FluorotryptaMine HCl
    T77673159730-09-3
    7-FluorotryptaMine HCl is a potent aromatic monoamine GPRC5A agonist that induces GPRC5A-mediated β-arrestin recruitment.7-FluorotryptaMine HCl can be used to study signalling pathways related to immunity and cancer.
    • $31
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  • VUF11207 fumarate
    T133241785665-61-3
    VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).
    • $36
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  • Barbadin
    T14498356568-70-2
    Barbadin is a novel and specific inhibitor of β-arrestin/β2-adaptin interaction with an IC50 value of 19.1 μM for β-arestin1 and 15.6 μM for β-arestin2. Barbadin potentiates the long term effects of lorcaserin on POMC neurons and weight loss. Barbadin potentiates the long-term effects of lorcaserin on POMC neurons and weight loss, blocks agonist-promoted endocytosis of prototypic β2-adrenergic, V2-vasopressin, and angiotensin-II-1 receptors, and may be useful in the study of obesity.
    • $199
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  • GAT211
    T27405102704-40-5
    GAT211 (AZ-4) is a selective and potent cannabinoid 1 receptor (CB1R) orthosteric modulator (PAM) with high affinity for cAMP and β-arrestin2.GAT211 has IOP-lowering and antipsychotic effects and can be used in the study of epilepsy.
    • $30
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  • CCX777
    T238661226686-36-7
    CCX777 is a partial agonist recruited to ACKR3 by β-arrestin-2 and is used in cancer research.
    • $299
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  • TRV-120027 TFA
    TP2158
    TRV120027 TFA is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R) and engages ß-arrestins while blocking G-protein signaling.
    • $64
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  • ML192
    T33452460331-61-7
    ML192 (CID1434953) is a selective GPR55 ligand antagonist. ML192 is an inhibitor that inhibits β-arrestin transport, ERK1/2 phosphorylation, and PKCβII translocation.
    • $46
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  • ML417
    T84231386162-69-1
    ML417 is a selective and brain penetrant agonist of D3 Dopamine (EC50 : 38 nM).
    • $34
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