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Duloxetine hydrochloride

Name: Duloxetine hydrochloride
Brand: TargetMol
SKU: T1471
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1471Cas No. 136434-34-9

Alias LY-248686 hydrochloride, LY-248686 HCl, Duloxetine HCl, (S)-Duloxetine hydrochloride

Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a thiophene derivative and selective neurotransmitter uptake inhibitor for serotonin and noradrenaline (SNRI). It is an antidepressant agent and anxiolytic, also used for treating pain in patients with diabetes mellitus and fibromyalgia.

Duloxetine hydrochloride

🥰Excellent

Purity: 99.93%

Catalog No. T1471Alias LY-248686 hydrochloride, LY-248686 HCl, Duloxetine HCl, (S)-Duloxetine hydrochlorideCas No. 136434-34-9

Pack Size	Price	Availability
10 mg	$48	In Stock
50 mg	$78	In Stock
100 mg	$108	In Stock
200 mg	$135	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Purity:99.93%

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Product Introduction

Bioactivity

Description	Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a thiophene derivative and selective neurotransmitter uptake inhibitor for serotonin and noradrenaline (SNRI). It is an antidepressant agent and anxiolytic, also used for treating pain in patients with diabetes mellitus and fibromyalgia.
Targets&IC50	SNRI:4.6 nM(Ki)
Synonyms	LY-248686 hydrochloride, LY-248686 HCl, Duloxetine HCl, (S)-Duloxetine hydrochloride

Chemical Properties

Molecular Weight	333.88
Formula	C₁₈H₂₀ClNOS
Cas No.	136434-34-9
Smiles	s1cccc1[C@@H](Oc1cccc2c1cccc2)CCNC.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (119.8 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9951 mL	14.9754 mL	29.9509 mL	149.7544 mL
5 mM	0.5990 mL	2.9951 mL	5.9902 mL	29.9509 mL
10 mM	0.2995 mL	1.4975 mL	2.9951 mL	14.9754 mL
20 mM	0.1498 mL	0.7488 mL	1.4975 mL	7.4877 mL
50 mM	0.0599 mL	0.2995 mL	0.5990 mL	2.9951 mL
100 mM	0.0300 mL	0.1498 mL	0.2995 mL	1.4975 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc