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Halofuginone hydrobromide
🥰Excellent
Catalog No. T3524Cas No. 64924-67-0
Alias Tempostatin, Stenorol, RU-19110 (hydrobromide)
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.
Halofuginone hydrobromide
🥰Excellent
Purity: 99.73%
Catalog No. T3524Alias Tempostatin, Stenorol, RU-19110 (hydrobromide)Cas No. 64924-67-0
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $31 | In Stock | |
| 2 mg | $44 | In Stock | |
| 5 mg | $72 | In Stock | |
| 10 mg | $114 | In Stock | |
| 25 mg | $230 | In Stock | |
| 50 mg | $345 | In Stock | |
| 100 mg | $520 | In Stock | |
| 500 mg | $996 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $81 | In Stock |
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Purity:99.73%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases. |
| Targets&IC50 | Prolyl-tRNA synthetase:18.3±0.5 nM(ki) |
| Synonyms | Tempostatin, Stenorol, RU-19110 (hydrobromide) |
| Molecular Weight | 495.59 |
| Formula | C16H17BrClN3O3.HBr |
| Cas No. | 64924-67-0 |
| Smiles | Br.O[C@H]1CCCN[C@@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 12 mg/mL (24.21 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
type-ITransforming growth factor betaTGF-β/SmadTGF-βTGFβTGF-beta/SmadTGFbeta/SmadTGF-betaTGFbetaTGF-b/SmadTGFbSodiumChannelSodium ChannelSmadRU-19110RU19110RU 19110RNASynthesisRNA SynthesisProRSprolyl-tRNA synthetaseprolyl-tRNAParasiteosteoarthritisNa+ channelsNa channelsInhibitorinhibitHalofuginone hydrobromideHalofuginone HydrobromideHalofuginoneDNASynthesisDNA/RNA SynthesisDNA SynthesisCalciumChannelCalcium ChannelCa2+ channelsCa channels
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