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Yohimbine hydrochloride

🥰Excellent
Catalog No. T2142Cas No. 65-19-0
Alias Yohimbine HCl, Antagonil

Yohimbine hydrochloride is a plant-derived alkaloid with alpha-2 adrenergic receptor blocking activity. By blocking presynaptic or postsynaptic alpha-2 adrenergic receptors, it promotes the release of norepinephrine and dopamine. It has been used in studies related to mydriasis and erectile dysfunction and is commonly used to induce hypertension models.

Yohimbine hydrochloride
Other Forms of Yohimbine hydrochloride:

Yohimbine hydrochloride

🥰Excellent
Purity: 100%
Catalog No. T2142Alias Yohimbine HCl, AntagonilCas No. 65-19-0
Yohimbine hydrochloride is a plant-derived alkaloid with alpha-2 adrenergic receptor blocking activity. By blocking presynaptic or postsynaptic alpha-2 adrenergic receptors, it promotes the release of norepinephrine and dopamine. It has been used in studies related to mydriasis and erectile dysfunction and is commonly used to induce hypertension models.
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200 mg$29In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Yohimbine hydrochloride is a plant-derived alkaloid with alpha-2 adrenergic receptor blocking activity. By blocking presynaptic or postsynaptic alpha-2 adrenergic receptors, it promotes the release of norepinephrine and dopamine. It has been used in studies related to mydriasis and erectile dysfunction and is commonly used to induce hypertension models.
In vivo
LD50: 55 mg/kg,i.p.,mice
AliasYohimbine HCl, Antagonil
Chemical Properties
Molecular Weight390.9
FormulaC21H27ClN2O3
Cas No.65-19-0
SmilesCOC(=O)[C@H]1[C@H](CC[C@@H]2[C@@H]1C[C@H]3C4=C(CCN3C2)C5=CC=CC=C5N4)O.Cl
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 42.5 mg/mL (108.72 mM), Sonication is recommended.
H2O: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5582 mL12.7910 mL25.5820 mL127.9100 mL
5 mM0.5116 mL2.5582 mL5.1164 mL25.5820 mL
10 mM0.2558 mL1.2791 mL2.5582 mL12.7910 mL
20 mM0.1279 mL0.6395 mL1.2791 mL6.3955 mL
50 mM0.0512 mL0.2558 mL0.5116 mL2.5582 mL
100 mM0.0256 mL0.1279 mL0.2558 mL1.2791 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

α2 adrenergic receptorYohimbine HydrochlorideYohimbine hydrochlorideYohimbineInhibitorinhibitBeta ReceptorAdrenergicReceptorAdrenergic Receptor
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