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Nootkatone

Name: Nootkatone
Brand: TargetMol
SKU: T3S0195
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3S0195Cas No. 4674-50-4

1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent obesity and improve physical performance through AMPK activation in skeletal muscle and liver.

Nootkatone

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Purity: 99.4%

Catalog No. T3S0195Cas No. 4674-50-4

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$40	-	In Stock
500 mg	$92	-	In Stock
1 g	$133	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.4%

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Nootkatone AI Summary

Nootkatone exhibits a range of bioactivities across different biological systems. It effectively inhibits cell degranulation in rat RBL2H3 cells and demonstrates significant inhibition of LPS-induced nitric oxide (NO) production in ddY mouse macrophages, with an IC50 value of 34000.0 nM. Additionally, it has antiproliferative effects against human A549 and HL60 cells, with ID50 values of 58.4 µg/ml and 4.27 µg/ml, respectively. The compound also shows activity against human liver transporters, significantly inhibiting OATP2B1 and slightly inhibiting OATP1B3, while stimulating OATP1B1. In terms of insect repellency, it is effective against Coptotermes formosanus at a concentration of 12.5 µg/g up to 24 hours, and it exhibits cytotoxicity against mouse BV2 cells with a maximum non-toxic concentration of 0.1 µM. Furthermore, Nootkatone acts as an antagonist at human TRPV1 and ORAI1 receptors at 90 µM, impacting capsaicin-induced inward currents. It also inhibits CYP2C19 enzyme activity, showing 70.0% inhibition at 1 µM and 21.9% inhibition at 10 µM concentrations relative to control..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	218.33
Formula	C₁₅H₂₂O
Cas No.	4674-50-4
Smiles	C[C@@H]1CC(=O)C=C2CC[C@H](C[C@@]12C)C(C)=C
Relative Density.	0.997

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1145.06 mM), Sonication is recommended.

Ethanol: Slightly soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5802 mL	22.9011 mL	45.8022 mL	229.0111 mL
5 mM	0.9160 mL	4.5802 mL	9.1604 mL	45.8022 mL
10 mM	0.4580 mL	2.2901 mL	4.5802 mL	22.9011 mL
20 mM	0.2290 mL	1.1451 mL	2.2901 mL	11.4506 mL
50 mM	0.0916 mL	0.4580 mL	0.9160 mL	4.5802 mL
100 mM	0.0458 mL	0.2290 mL	0.4580 mL	2.2901 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc