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PI3Kδ-IN-3

Name: PI3Kδ-IN-3
Brand: TargetMol
SKU: T26252
Price: 86 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26252Cas No. 1431540-99-6

Alias TC KHNS 11

PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function.

PI3Kδ-IN-3

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Purity: 99.8%

Catalog No. T26252Alias TC KHNS 11Cas No. 1431540-99-6

PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$86	-	In Stock
5 mg	$195	-	In Stock
10 mg	$311	-	In Stock
25 mg	$529	-	In Stock
50 mg	$765	-	In Stock
100 mg	$1,070	-	In Stock
500 mg	$2,150	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.8%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

PI3Kδ-IN-3 AI Summary

PI3Kδ-IN-3 exhibits bioactivity as a potent inhibitor of phosphatidylinositol 3-kinase (PI3K), with specificity and high potency towards the PI3K-delta isoform. This is supported by low IC50 values across various assays, including inhibition in rat blood, Balb/c mouse splenocytes, and other cell types, resulting in reduced ADP formation, Ak phosphorylation, and CD86 expression upon stimulation. PI3Kδ-IN-3 also demonstrates notable selectivity for PI3K-delta over other PI3K isoforms (alpha, beta, gamma), favorable solubility at pH 6.8, and beneficial lipophilicity indicated by log P values. Additionally, it shows good oral bioavailability, drug uptake, and favorable pharmacokinetic properties, including moderate clearance, volume of distribution, and terminal half-life in different species..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function.
Targets&IC50	PI3Kδ:9 nM, PI3Kβ:1.65 μM, PI3Kα:0.262 μM, PI3Kγ:4.63 μM
Synonyms	TC KHNS 11

Chemical Properties

Molecular Weight	492.53
Formula	C₂₈H₂₄N₆O₃
Cas No.	1431540-99-6
Smiles	C(=O)(C=1C=C(C=2C3=C(C=CC(=C3)C=4C=C(C#N)C(OC)=NC4)N=CN2)C=CC1)N5CCN(C(C)=O)CC5
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (101.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0303 mL	10.1517 mL	20.3033 mL	101.5167 mL
5 mM	0.4061 mL	2.0303 mL	4.0607 mL	20.3033 mL
10 mM	0.2030 mL	1.0152 mL	2.0303 mL	10.1517 mL
20 mM	0.1015 mL	0.5076 mL	1.0152 mL	5.0758 mL
50 mM	0.0406 mL	0.2030 mL	0.4061 mL	2.0303 mL
100 mM	0.0203 mL	0.1015 mL	0.2030 mL	1.0152 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc