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α-Conotoxin Vc1.1 TFA

Name: α-Conotoxin Vc1.1 TFA
Brand: TargetMol
SKU: T73894
Rating: 4.5 (1 reviews)

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Catalog No. T73894

α-Conotoxin Vc1.1 TFA is a peptide isolated from Conus victoriae and a selective nAChR antagonist that inhibits α3α5β2, α3β2 and α3β4, reversing mechanical allodynia in neuropathic pain models and can be used to study neuropathic chronic pain. α-Conotoxin Vc1.1 TFA inhibits human dorsal root ganglion nerve excitability and mouse colon nociception via GABA(B) receptors.

α-Conotoxin Vc1.1 TFA

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Purity: 97.57%

Catalog No. T73894

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$143	Inquiry	Inquiry
5 mg	$363	Inquiry	Inquiry
10 mg	$579	Inquiry	Inquiry
25 mg	$891	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.57%

Resource Download

COA HPLC MS

Product Introduction

Bioactivity

Description	α-Conotoxin Vc1.1 TFA is a peptide isolated from Conus victoriae and a selective nAChR antagonist that inhibits α3α5β2, α3β2 and α3β4, reversing mechanical allodynia in neuropathic pain models and can be used to study neuropathic chronic pain. α-Conotoxin Vc1.1 TFA inhibits human dorsal root ganglion nerve excitability and mouse colon nociception via GABA(B) receptors.
Targets&IC50	α3α5β2:7.2 μM, α3β4:4.2 μM, α3β2:7.3 μM
In vitro	α-Conotoxin Vc1.1 TFA is a selective nAChR antagonist. α-Conotoxin Vc1.1 TFA inhibits α3α5β2(IC50=7.2 μM), α3β2(IC50=7.3 μM) and α3β4(IC50=4.2 μM) and has less inhibitory effect on other nAChR subtypes. [1]
In vivo	Once-daily intramuscular injection of 0.18-18 μg/μL α-Conotoxin Vc1.1 TFA for 7 consecutive days in male Sprague-Dawley rats suppressed pain behavior and accelerated functional recovery of damaged neurons in a sciatic nerve chronic compression injury (CCI) model. [2]

Chemical Properties

Molecular Weight	1925.03
Formula	C₇₃H₁₀₈F₃N₂₃O₂₇S₄
Smiles	[H]NCC(N[C@@H](CS)C(N[C@@H](CS)C(N[C@H](C(N[C@@H](CC(O)=O)C(N1CCC[C@H]1C(N[C@H](C(N[C@@H](CS)C(N[C@H](C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC3=CN=CN3)C(N4CCC[C@H]4C(N[C@H](C(N[C@]([H])(C(N[C@@H](CS)C(N)=O)=O)[C@@H](C)CC)=O)CCC(O)=O)=O)=O)=O)=O)=O)CC(N)=O)=O)=O)CCCNC(N)=N)=O)=O)=O)CO)=O)=O)=O.O=C(O)C(F)(F)F
Color	White
Appearance	Solid
Sequence	Gly-Cys-Cys-Ser-Asp-Pro-Arg-Cys-Asn-Tyr-Asp-His-Pro-Glu-Ile-Cys-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys16)
Sequence Short	GCCSDPRCNYDHPEIC-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys16)

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (41.56 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (1.71 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.5195 mL	2.5974 mL	5.1947 mL	25.9736 mL
5 mM	0.1039 mL	0.5195 mL	1.0389 mL	5.1947 mL
10 mM	0.0519 mL	0.2597 mL	0.5195 mL	2.5974 mL
20 mM	0.0260 mL	0.1299 mL	0.2597 mL	1.2987 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc