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PZL-A
🥰Excellent
Catalog No. T204002Cas No. 3068830-89-4
Alias PZLA, 1-[(4S)-8-Chlorochroman-4-yl)-3-(1-phenylpyrazol-3-yl)urea
PZL-A (PZL-A), an activator of mtDNA synthesis, restored the function and activity of the most common POLγ mutant variant and activated mtDNA synthesis in the cells of pediatric patients with fatal diseases, thereby enhancing the oxidative phosphorylation mechanism and the biogenesis of cellular respiration, and can be used to treat progressive diseases associated with mtDNA depletion.
PZL-A
🥰Excellent
Purity: 100%
Catalog No. T204002Alias PZLA, 1-[(4S)-8-Chlorochroman-4-yl)-3-(1-phenylpyrazol-3-yl)ureaCas No. 3068830-89-4
PZL-A (PZL-A), an activator of mtDNA synthesis, restored the function and activity of the most common POLγ mutant variant and activated mtDNA synthesis in the cells of pediatric patients with fatal diseases, thereby enhancing the oxidative phosphorylation mechanism and the biogenesis of cellular respiration, and can be used to treat progressive diseases associated with mtDNA depletion.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $340 | In Stock | |
| 5 mg | $740 | In Stock | |
| 10 mg | $1,120 | In Stock | |
| 25 mg | $1,900 | In Stock | |
| 50 mg | $2,840 | In Stock | |
| 100 mg | $4,260 | In Stock |
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Purity:100%
ee:99.66%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PZL-A (PZL-A), an activator of mtDNA synthesis, restored the function and activity of the most common POLγ mutant variant and activated mtDNA synthesis in the cells of pediatric patients with fatal diseases, thereby enhancing the oxidative phosphorylation mechanism and the biogenesis of cellular respiration, and can be used to treat progressive diseases associated with mtDNA depletion. |
| In vitro | PZL-A (1 μM; 37 °C, 15–60 min) enhanced DNA polymerase activity of mutant POLγ complexes in primer extension assays using recombinant enzymes and M13 ssDNA. PZL-A improved processivity without affecting exonuclease function[1].PZL-A (≥10 nM; 4–7 d) promoted mtDNA recovery and improved mitochondrial function in POLG-mutant patient fibroblasts and neural stem cells after ethidium bromide–induced depletion[1]. |
| Alias | PZLA, 1-[(4S)-8-Chlorochroman-4-yl)-3-(1-phenylpyrazol-3-yl)urea |
| Molecular Weight | 368.82 |
| Formula | C19H17ClN4O2 |
| Cas No. | 3068830-89-4 |
| Smiles | N(C(NC1=NN(C=C1)C2=CC=CC=C2)=O)[C@@H]3C=4C(OCC3)=C(Cl)C=CC4 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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