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Anti-ENTPD5 Antibody (8M811)
😃Good
Catalog No. TMAY-01723
Alias Pcph, NTPDase-5, NTPDase5, mNTPase, ER-UDPase, ectonucleoside triphosphate diphosphohydrolase 5, Cd39l4, AI987697, AI196558
Anti-ENTPD5 Antibody (8M811) is a Mouse antibody targeting ENTPD5. Anti-ENTPD5 Antibody (8M811) can be used in IHC-P.
Anti-ENTPD5 Antibody (8M811)
Anti-ENTPD5 Antibody (8M811)
😃Good
Catalog No. TMAY-01723Alias Pcph, NTPDase-5, NTPDase5, mNTPase, ER-UDPase, ectonucleoside triphosphate diphosphohydrolase 5, Cd39l4, AI987697, AI196558
Anti-ENTPD5 Antibody (8M811) is a Mouse antibody targeting ENTPD5. Anti-ENTPD5 Antibody (8M811) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: IHC-P Reactivity: Human |
| Alias | Pcph, NTPDase-5, NTPDase5, mNTPase, ER-UDPase, ectonucleoside triphosphate diphosphohydrolase 5, Cd39l4, AI987697, AI196558 |
| Ig Type | Mouse IgG1 |
| Clone | 8M811 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human ENTPD5 in human prostate with mouse monoclonal antibody (1:30, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human ENTPD5 in human kidney with mouse monoclonal antibody (1:30, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:20-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ENTPD5 (rh ENTPD5; TMPY-02758; O75356; Met1-His428). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), also known as CD39 antigen-like 4, ER-UDPase, Guanosine-diphosphatase ENTPD5, Nucleoside diphosphatase Uridine-diphosphatase ENTPD5. This hydrolase is expressed in response to phosphoinositide 3-kinase (PI3K) signaling. Activation of PI3K results in FOXO phosphorylation by AKT1 and loss of ENTPD5 transcriptional repression. It is Up-regulated in PTEN-deficient cells. Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation.ENTPD5 promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, ENTPD5 constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. ENTPD5 also hydrolyzes GDP and IDP but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. This enzyme Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human ENTPD5 Protein (TMPY-02758) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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