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Beauvericin

Name: Beauvericin
Brand: TargetMol
SKU: T14523
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14523Cas No. 26048-05-5

Beauvericin, a Fusarium mycotoxin, inhibits acyl-CoA:cholesterol acyltransferase (ACAT) in rat liver microsomal enzyme assays with an IC50 value of 3 μM.

Beauvericin

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Catalog No. T14523Cas No. 26048-05-5

Beauvericin, a Fusarium mycotoxin, inhibits acyl-CoA:cholesterol acyltransferase (ACAT) in rat liver microsomal enzyme assays with an IC50 value of 3 μM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	In Stock	In Stock
5 mg	$148	-	In Stock
10 mg	$218	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:≥98%

Appearance:Solid

Color:White

Resource Download

COA HNMR

Product Introduction

Beauvericin AI Summary

Beauvericin exhibits significant antifungal activity against Candida albicans ATCC 24433, with a MIC of >100.0 μg/mL in a standard broth microdilution assay. Its antifungal efficacy improves substantially when combined with fluconazole, reducing the MIC to 1.3 μg/mL, indicative of a synergistic effect. This synergy is further supported by a low fractional inhibition concentration ratio and index. The compound also demonstrates antibiofilm activity, achieving a MIC=>80 of 40.0 μg/mL in the presence of fluconazole, again displaying synergistic properties and potentiation of fluconazole's activity. In addition to its antifungal properties, Beauvericin shows antiproliferative effects against various cell lines. It exhibits an IC50 of 4300.0 nM against human Huh-7 liver cancer cells, 8700.0 nM against rat MRMT-1 mammary carcinoma cells, and 1000.0 nM against human HepG2 liver cancer cells, as determined by the CCK-8 assay after 48 hours of treatment. Furthermore, the compound inhibits SOAT activity in mouse J774 macrophages with an IC50 of 5600.0 nM. Overall, Beauvericin demonstrates promising antifungal, antibiofilm, and antiproliferative activities, making it a potential candidate for further development in both antimicrobial and anticancer therapies..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Beauvericin, a Fusarium mycotoxin, inhibits acyl-CoA:cholesterol acyltransferase (ACAT) in rat liver microsomal enzyme assays with an IC50 value of 3 μM.
Targets&IC50	ACAT:3 μM

Chemical Properties

Molecular Weight	783.95
Formula	C₄₅H₅₇N₃O₉
Cas No.	26048-05-5
Smiles	CC(C)[C@H]1OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](OC(=O)[C@H](Cc2ccccc2)N(C)C1=O)C(C)C)C(C)C
Relative Density.	1.31g/cm3
Sequence	cyclo[D-OVal-N(Me)Phe-D-OVal-N(Me)Phe-D-OVal-N(Me)Phe]
Sequence Short	cyclo(VFVFVF)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 78.4 mg/mL (100.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2756 mL	6.3780 mL	12.7559 mL	63.7796 mL
5 mM	0.2551 mL	1.2756 mL	2.5512 mL	12.7559 mL
10 mM	0.1276 mL	0.6378 mL	1.2756 mL	6.3780 mL
20 mM	0.0638 mL	0.3189 mL	0.6378 mL	3.1890 mL
50 mM	0.0255 mL	0.1276 mL	0.2551 mL	1.2756 mL
100 mM	0.0128 mL	0.0638 mL	0.1276 mL	0.6378 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc