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Butenafine hydrochloride

Name: Butenafine hydrochloride
Brand: TargetMol
SKU: T1217
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1217Cas No. 101827-46-7

Alias KP-363 HCl, KP363 (Hydrochloride), Butenafine HCl

Butenafine hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, inhibiting the synthesis of sterols by inhibiting squalene epoxidase.

Butenafine hydrochloride

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Purity: 99.66%

Catalog No. T1217Alias KP-363 HCl, KP363 (Hydrochloride), Butenafine HClCas No. 101827-46-7

Butenafine hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, inhibiting the synthesis of sterols by inhibiting squalene epoxidase.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$31	In Stock	In Stock
500 mg	$53	-	In Stock
1 g	$81	-	In Stock
1 mL x 10 mM (in DMSO)	$57	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.66%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Butenafine hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, inhibiting the synthesis of sterols by inhibiting squalene epoxidase.
In vitro	Butenafine HCl shows minimum inhibitory concentrations ranging from 0.03–1.0 μg/mL against 30 isolates representing different dermatophyte species. Butenafine shows limited activity against C. albicans and no activity against M. furfur against 10 isolates of two species of yeasts. Butenafine HCl shows activity against β-hemolytic Streptococcus Group A and Corynebacterium but failed to inhibit S. aureus against 25 isolates representing different Gram-positive bacteria species. Butenafine fails to show activity against any of the Gram-negative strains tested. [1] Butenafine interferes with fungal ergosterol biosynthesis by inhibiting the conversion of squalene into squalene epoxide which is catalyzed by squalene epoxidase. Butenafine shows activity against KD-04 and KD-305 with minimum inhibitory concentrations of 12 ng/mL. [2]
In vivo	Butenafine (1%, once daily) shows excellent efficacy against dermatophytosis in male hartley strain guinea pigs, and the effect is superior to those of naftifine, tolnaftate, clotrimazole, and bifonazole. Butenafine (1%) exhibits excellent prophylactic efficacy against experimental T. mentagrophytes infection when apply once at 24 or 48 h before infection. [2] After 16 weeks, 80% of patients using medicated cream incorporating 2% butenafine HCl are cured, as opposed to none in the placebo group. Four patients in the active treatment group experience subjective mild inflammation without discontinuing treatment. During follow-up, no relapse occurres in cured patients and no improvement is seen in medication-resistant and placebo participants. [3] Butenafine (1% cream) applied once daily for 4 weeks results in an effective clinical response and mycologic cure of tinea pedis during treatment in patients with positive fungal cultures. [4] Butenafine hydrochloride (1% cream) alone is extremely effective for the treatment of hyperkeratotic-type tinea pedis patients. [5]
Synonyms	KP-363 HCl, KP363 (Hydrochloride), Butenafine HCl

Chemical Properties

Molecular Weight	353.93
Formula	C₂₃H₂₇N·HCl
Cas No.	101827-46-7
Smiles	Cl.C(c1ccc(cc1)CN(C)Cc1cccc2c1cccc2)(C)(C)C
Relative Density.	1.032g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (127.14 mM), Sonication is recommended.

Ethanol: 65 mg/mL (183.65 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.65 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.8254 mL	14.1271 mL	28.2542 mL	141.2709 mL
5 mM	0.5651 mL	2.8254 mL	5.6508 mL	28.2542 mL
10 mM	0.2825 mL	1.4127 mL	2.8254 mL	14.1271 mL
20 mM	0.1413 mL	0.7064 mL	1.4127 mL	7.0635 mL
50 mM	0.0565 mL	0.2825 mL	0.5651 mL	2.8254 mL
100 mM	0.0283 mL	0.1413 mL	0.2825 mL	1.4127 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc