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Anti-PVRL1/NECTIN1 Antibody-PE (3U994)
🥰Excellent
Catalog No. TMAY-01929P
Anti-PVRL1/NECTIN1 Antibody-PE (3U994) is a PE-conjugated Mouse antibody targeting PVRL1/NECTIN1. Anti-PVRL1/NECTIN1 Antibody-PE (3U994) can be used in FCM.
Anti-PVRL1/NECTIN1 Antibody-PE (3U994)
Anti-PVRL1/NECTIN1 Antibody-PE (3U994)
🥰Excellent
Catalog No. TMAY-01929P
Anti-PVRL1/NECTIN1 Antibody-PE (3U994) is a PE-conjugated Mouse antibody targeting PVRL1/NECTIN1. Anti-PVRL1/NECTIN1 Antibody-PE (3U994) can be used in FCM.
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Chemical Properties
| Description | Anti-PVRL1/NECTIN1 Antibody-PE (3U994) is a PE-conjugated Mouse antibody targeting PVRL1/NECTIN1. Anti-PVRL1/NECTIN1 Antibody-PE (3U994) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2b |
| Clone | 3U994 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of anti-human PVRL1 (CD111) on human erythroleukemia cell line TF-1. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD111 / Nectin-1 / PVRL1 (rh CD111 / Nectin-1 / PVRL1; TMPY-01572; NP_002846.3; Met 1-Thr 334) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | Poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin-1; CD111), also known as PVRL1 is a cell adhesion molecule belonging to the immunoglobulin superfamily that can bind to virion glycoprotein D (gD) to mediate entry of herpes simplex viruses (HSV) and pseudorabies virus (PRV). CD111/Nectin-1/PVRL1 colocalizes with E-cadherin at adherens junctions in epithelial cells. The disruption of cell junctions can result in the redistribution of nectin-1. To determine whether disruption of junctions by calcium depletion influenced the susceptibility of epithelial cells to viral entry, Madin-Darby canine kidney cells expressing endogenous nectin-1 or transfected human nectin-1 were tested for the ability to bind soluble forms of viral gD and to be infected by HSV and PRV, before and after calcium depletion. It has been revealed that binding of HSV and PRV gD was localized to adherens junctions in cells maintained in normal medium but was distributed, along with nectin-1, over the entire cell surface after calcium depletion. Both the binding of gD and the fraction of cells that could be infected by HSV-1 and PRV were enhanced by calcium depletion. Taken together, CD111/Nectin-1/PVRL1 confined to adherens junctions in epithelial cells is not very accessible to virus, whereas dissociation of cell junctions releases nectin-1 to serve more efficiently as an entry recptor. |
| Conjucates | PE |
| Others Formats | Unconjugated/APC |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Human CD111 / Nectin-1 / PVRL1 protein (TMPY-01572) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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