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Anti-Phospho-FOXO3 (Ser253) Antibody (8Z418)
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Catalog No. TMAH-00898
Alias Phospho-FOXO3 (S253), p-FOXO3 (Ser253), p-FOXO3 (S253), MGC31925, MGC12739, FOXO3A, FOXO3 (p-Ser253), FOXO3 (p-S253), FOX O3A, Forkhead in rhabdomyosarcoma-like 1, Forkhead homolog (rhabdomyosarcoma) like 1, Forkhead Drosophila homolog of in rhabdomyosarcoma like 1, Forkhead box O3A, Forkhead box O3, Forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1, FKHRL1P2, FKHRL1, FKHRL 1, FKHR2, DKFZp781A0677, AF6q21
Anti-Phospho-FOXO3 (Ser253) Antibody (8Z418) is an antibody targeting Phospho-FOXO3 (Ser253). Anti-Phospho-FOXO3 (Ser253) Antibody (8Z418) can be used in ELISA, WB, IHC.
Anti-Phospho-FOXO3 (Ser253) Antibody (8Z418)
Anti-Phospho-FOXO3 (Ser253) Antibody (8Z418)
😃Good
Catalog No. TMAH-00898Alias Phospho-FOXO3 (S253), p-FOXO3 (Ser253), p-FOXO3 (S253), MGC31925, MGC12739, FOXO3A, FOXO3 (p-Ser253), FOXO3 (p-S253), FOX O3A, Forkhead in rhabdomyosarcoma-like 1, Forkhead homolog (rhabdomyosarcoma) like 1, Forkhead Drosophila homolog of in rhabdomyosarcoma like 1, Forkhead box O3A, Forkhead box O3, Forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1, FKHRL1P2, FKHRL1, FKHRL 1, FKHR2, DKFZp781A0677, AF6q21
Anti-Phospho-FOXO3 (Ser253) Antibody (8Z418) is an antibody targeting Phospho-FOXO3 (Ser253). Anti-Phospho-FOXO3 (Ser253) Antibody (8Z418) can be used in ELISA, WB, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $209 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Rabbit Monoclonal Application: ELISA, WB, IHC Reactivity: Human |
| Alias | Phospho-FOXO3 (S253), p-FOXO3 (Ser253), p-FOXO3 (S253), MGC31925, MGC12739, FOXO3A, FOXO3 (p-Ser253), FOXO3 (p-S253), FOX O3A, Forkhead in rhabdomyosarcoma-like 1, Forkhead homolog (rhabdomyosarcoma) like 1, Forkhead Drosophila homolog of in rhabdomyosarcoma like 1, Forkhead box O3A, Forkhead box O3, Forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1, FKHRL1P2, FKHRL1, FKHRL 1, FKHR2, DKFZp781A0677, AF6q21 |
| Ig Type | Rabbit IgG |
| Clone | 8Z418 |
| Reactivity | Human |
| Verified Activity | 1. Western Blot -Positive WB detected in Hela whole cell lysate, 293 whole cell lysate, A549 whole cell lysate -All lanes Phospho-FOXO3 antibody at 0.96μg/ml -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 97 KDa -Observed band size: 97 KDa 2. IHC image of TMAH-00898 diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. 3. IHC image of TMAH-00898 diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Application | ELISA, WB, IHC |
| Recommended Dose | WB:1:500-1:5000; IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm, cytosol. Nucleus. Mitochondrion matrix. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy. Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins. Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation. Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Phospho-FOXO3 (S253) |
| Antigen Species | Human |
| Gene ID | 2309 |
| Uniprot ID | |
| Biology Area | Epigenetics and Nuclear Signaling |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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