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Adenosine
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Catalog No. T0853Cas No. 58-61-7
Alias D-Adenosine, Adenine riboside
Adenosine (D-Adenosine) is a natural product, a ribonucleoside consisting of adenine bound to ribose. Adenosine has vasodilatory, antiarrhythmic and analgesic effects.
Adenosine
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Purity: 99.86%
Catalog No. T0853Alias D-Adenosine, Adenine ribosideCas No. 58-61-7
Adenosine (D-Adenosine) is a natural product, a ribonucleoside consisting of adenine bound to ribose. Adenosine has vasodilatory, antiarrhythmic and analgesic effects.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 mg | $37 | In Stock | In Stock | |
| 1 g | $46 | In Stock | In Stock | |
| 5 g | $75 | - | In Stock | |
| 10 g | $98 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.86%
Color:White
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Product Introduction
Adenosine AI Summary
Adenosine is a bioactive molecule exhibiting a wide range of biological activities across various assays and disease models. It acts as a substrate for adenosine deaminase with different Km values reported in various contexts, and it demonstrates inhibition of adenosine receptor binding (Ki values: A1 receptor at 12.8 nM, A2 receptor at 37.0 nM). This compound selectively inhibits adenosine kinase and impacts human CEM lymphoblast proliferation (ED50 of 10.0 µM and ID50 of 10.0 µM). It shows binding affinity to Toxoplasma gondii adenosine kinase (Km of 2400.0 nM) and Trypanosoma brucei Phosphoglycerate kinase with an IC50 of 3,000,000 nM.
Additionally, Adenosine inhibits synaptic potential in the hippocampal formation (IC50 of 26,000 nM) and exhibits variable potency in relaxation assays on vascular smooth muscle. It also inhibits S-adenosyl-L-homocysteine hydrolase with a Km of 820.0 nM, and exhibits antiviral properties against HSV-1 and further impacts cellular DNA synthesis.
The compound's receptor activities extend to competitive inhibition at A1 and A2B receptors, and it also affects adenosine transport processes. In various assays, Adenosine shows a range of enzyme inhibitory activities, including the inhibition of adenosine transporters, phosphatidylinositol 4-kinase, and ADP-induced platelet aggregation.
Its therapeutic potential is highlighted by significant antitumor activities, with ID50 values ranging from 10.8 µM to 89.8 µM across different cell lines. Adenosine also exhibits coronary vasoactivity in dog models (EC50 of 0.12 nM) and has demonstrated potential in reducing virus yield in herpes virus models.
These diverse bioactivities indicate that Adenosine modulates multiple biological targets and pathways, making it a candidate for therapeutic exploration in cancer, cardiovascular, infectious diseases, and enzyme-related disorders..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Adenosine (D-Adenosine) is a natural product, a ribonucleoside consisting of adenine bound to ribose. Adenosine has vasodilatory, antiarrhythmic and analgesic effects. |
| Targets&IC50 | KKU-055 cells:1000 μM, RMCCA-1 cells:255 μM, KKU-213 cells:320 μM, HuCCA1 cells:270 μM |
| In vitro | METHODS: Human prostate cancer cells DU-145, PC3 and LNcap-FGC-10 were treated with Adenosine (0.1-1000 µM) for 48 h. Cell viability was measured by MTT assay. RESULTS: Adenosine significantly reduced cell proliferation of DU-145, PC3 and LNcap-FGC10 cell lines in a dose-dependent manner. [1] METHODS: Human hepatocellular carcinoma cells HepG2 were treated with Adenosine (2 mM) for 6-24 h. The cell cycle was detected by Flow cytometry. RESULTS: Adenosine-induced inhibition of survival was attributed to the arrest of cell cycle progression. Adenosine significantly increased the percentage of G0/G1-phase cells and decreased the percentage of S-phase and G2/M-phase cells in HepG2 cells. [2] |
| In vivo | METHODS: To investigate the antidepressant-like effects, Adenosine (1-10 mg/kg) was intraperitoneally injected into mice and subjected to the forced swimming test (FST) and tail suspension test (TST). RESULTS: The immobilization time in the FST was shortened by intraperitoneal injection of Adenosine (5-10 mg/kg), and Adenosine (1-10 mg/kg) also produced antidepressant-like effects in the TST. [3] |
| Synonyms | D-Adenosine, Adenine riboside |
| Molecular Weight | 267.24 |
| Formula | C10H13N5O4 |
| Cas No. | 58-61-7 |
| Smiles | O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CO)[C@H]1O |
| Relative Density. | 1.3382 g/cm3 (Estimated) |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 166.6 mg/mL (623.41 mM), Sonication is recommended.  H2O: 2.7 mg/mL (10.1 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 5% DMSO+95% Saline: 1.05 mg/mL (3.93 mM), Solution. 10% DMSO+90% Saline: 2 mg/mL (7.48 mM), Solution. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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