Neuroprotective agent 14

Name: Neuroprotective agent 14
Brand: TargetMol
SKU: T212951
Rating: 4.5 (1 reviews)

Catalog No. T212951 Copy Product Info

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Neuroprotective agent 14 is a 1H-benzimidazole [d] compound that can penetrate the blood-brain barrier and is known for its neuroprotective properties. It activates autophagy (autophagy) and reduces the accumulation of SCMAS in iPSC-derived neural progenitor cells. This agent is useful for studying neurological disorders such as neuronal ceroid lipofuscinoses (NCLs).

Neuroprotective agent 14

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Catalog No. T212951

Neuroprotective agent 14

Cas No. 3086460-57-0

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Neuroprotective agent 14 is a 1H-benzimidazole [d] compound that can penetrate the blood-brain barrier and is known for its neuroprotective properties. It activates autophagy (autophagy) and reduces the accumulation of SCMAS in iPSC-derived neural progenitor cells. This agent is useful for studying neurological disorders such as neuronal ceroid lipofuscinoses (NCLs).
In vitro	Neuroprotective agent 14 (Compound 38b) shows several beneficial effects: at a concentration of 10 μM over 24 hours, it enhances the viability of iPSC-derived neural progenitor cells (NPCs) afflicted with CLN3, achieving a maximum protective effect of 73.68%. Additionally, it reduces abnormal accumulation of mitochondrial ATP synthase subunit c (SCMAS) and activates the autophagy pathway in iPSC-NPCs from CLN3 patients. Neuroprotective agent 14, within the range of 1-10 μM, does not activate Kv7.2/7.3 voltage-gated potassium channels. Furthermore, this agent demonstrates the potential to cross the blood-brain barrier, with a binding rate of 96.25% in mouse brain homogenates.
In vivo	Neuroprotective agent 14 (Compound 38b), administered intravenously at 1 mg/kg and orally at 10 mg/kg, exhibits significant brain penetration in Balb/c mice, with brain-to-plasma concentration ratios of 3.2 and 4.5, respectively.

Chemical Properties

Molecular Weight	306.29
Formula	C₁₆H₁₃F₃N₂O
Cas No.	3086460-57-0
Smiles	FC(F)(F)C1=CC=C(C=C1)COC=2C=CC=3N=C(NC3C2)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc