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LY2880070

Name: LY2880070
Brand: TargetMol
SKU: T9252
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9252Cas No. 1375637-35-6

LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.

LY2880070

🥰Excellent

Purity: 99.77%

Catalog No. T9252Cas No. 1375637-35-6

LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.

Pack Size	Price	Availability
1 mg	$50	In Stock
5 mg	$120	In Stock
10 mg	$188	In Stock
25 mg	$370	In Stock
50 mg	$557	In Stock
100 mg	$793	In Stock
1 mL x 10 mM (in DMSO)	$126	In Stock

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Batch Information

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Purity:99.77%

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Bioactivity

Description

LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.

Chemical Properties

Molecular Weight	381.43
Formula	C₁₉H₂₃N₇O₂
Cas No.	1375637-35-6
Smiles	O(C)C1=C(C2=CC(NC3=NC(O[C@@H]4CCCNC4)=CN=C3)=NN2)C=CC(C)=N1
Relative Density.	1.293 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (157.3 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6217 mL	13.1086 mL	26.2171 mL	131.0857 mL
5 mM	0.5243 mL	2.6217 mL	5.2434 mL	26.2171 mL
10 mM	0.2622 mL	1.3109 mL	2.6217 mL	13.1086 mL
20 mM	0.1311 mL	0.6554 mL	1.3109 mL	6.5543 mL
50 mM	0.0524 mL	0.2622 mL	0.5243 mL	2.6217 mL
100 mM	0.0262 mL	0.1311 mL	0.2622 mL	1.3109 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc