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Anti-Cadherin 16/CDH16 Antibody (9V223)
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Catalog No. TMAY-01326
Alias UNQ695/PRO1340, cadherin 16
Anti-Cadherin 16/CDH16 Antibody (9V223) is a Mouse antibody targeting Cadherin 16/CDH16. Anti-Cadherin 16/CDH16 Antibody (9V223) can be used in IHC-P.
Anti-Cadherin 16/CDH16 Antibody (9V223)
Anti-Cadherin 16/CDH16 Antibody (9V223)
😃Good
Catalog No. TMAY-01326Alias UNQ695/PRO1340, cadherin 16
Anti-Cadherin 16/CDH16 Antibody (9V223) is a Mouse antibody targeting Cadherin 16/CDH16. Anti-Cadherin 16/CDH16 Antibody (9V223) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: IHC-P Reactivity: Human |
| Alias | UNQ695/PRO1340, cadherin 16 |
| Ig Type | Mouse IgG1 |
| Clone | 9V223 |
| Reactivity | Human |
| Verified Activity | Immunochemical staining of human CDH16 in human kidney with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:50-1:200 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human KSP-Cadherin / Cadherin-16 (rh KSP-Cadherin / Cadherin-16; TMPY-01763; NP_004053.1; Met1-Ala786). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | KSP-Cadherin/Cadherin-16 is a member of the cadherin superfamily, calcium-dependent, membrane-associated glycoproteins. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. KSP-Cadherin/Cadherin-16 can be detected at later stages of tubulogenesis during human renal development and in the distal tubules of adult kidneys, no expression was found by immunohistochemistry or Western blot analysis in RCC tumour tissues and several RCC cell lines. However, despite the lack of protein expression, mRNA synthesis of KSP-Cadherin/Cadherin-16 could be detected by reverse transcriptase-polymerase chain reaction analysis in all RCC tissues and most of the RCC cell lines studied, although at a reduced level. The loss of KSP-Cadherin/Cadherin-16 protein was only observed in the malignant part of the tumour kidneys, whereas in the normal part of the affected kidneys KSP-Cadherin/Cadherin-16 expression was clearly detected. These results indicate a downregulation of Ksp-cadherin in RCC and suggest a role for this cell adhesion molecule in tumour suppression. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human KSP-Cadherin / Cadherin-16 Protein (TMPY-01763) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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