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CSF1R-IN-23
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Catalog No. T86103Cas No. 2935480-17-2
CSF1R-IN-23 (Compound 7dri), a selective colony-stimulating factor-1 receptor (CSF1R) inhibitor, exhibits an IC50 of 36.1 nM. This compound acts as an antineuroinflammatory agent in a mouse model and is noted for its blood-brain barrier (BBB) permeability [1].
CSF1R-IN-23
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Catalog No. T86103Cas No. 2935480-17-2
CSF1R-IN-23 (Compound 7dri), a selective colony-stimulating factor-1 receptor (CSF1R) inhibitor, exhibits an IC50 of 36.1 nM. This compound acts as an antineuroinflammatory agent in a mouse model and is noted for its blood-brain barrier (BBB) permeability [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 8-10 weeks | 8-10 weeks | |
| 50 mg | $1,980 | 8-10 weeks | 8-10 weeks | |
| 100 mg | $2,500 | 8-10 weeks | 8-10 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | CSF1R-IN-23 (Compound 7dri), a selective colony-stimulating factor-1 receptor (CSF1R) inhibitor, exhibits an IC50 of 36.1 nM. This compound acts as an antineuroinflammatory agent in a mouse model and is noted for its blood-brain barrier (BBB) permeability [1]. |
| In vitro | CSF1R-IN-23, at concentrations of 0-10 μM for 30 minutes, inhibits CSF1R autophosphorylation in RAW264.7 cells and microglial cells EOC20 without significant cytotoxicity [1]. Western Blot Analysis [1]. Cell Line: EOC20 and RAW264.7. Concentration: 0-10 μM. Incubation Time: 30 min. Result: Inhibited phosphorylation of CSF1R. |
| In vivo | CSF1R-IN-23, administered at 0.5 mg/kg via intraperitoneal injection every two days for a total of four doses, can ameliorate neuroinflammation induced by lipopolysaccharide in the C57BL/6J mouse model [1]. In this model, 76% of microglia in the hippocampus, cortex, and thalamus are eliminated. Animal Model: LPS-induced neuroinflammation in C57BL/6J mice [1]. Dosage: 0.5 mg/kg. Administration: i.p., every two days for four doses. Result: Eliminated 76% of microglia in hippocampus, cortex, and thalamus. |
| Molecular Weight | 435.6 |
| Formula | C27H37N3O2 |
| Cas No. | 2935480-17-2 |
| Smiles | N(C(=O)C1=NOC(C)=C1)C2=C(C=C(C=C2)C3CC(C)(C)NC(C)(C)C3)C=4CCC(C)CC4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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