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TMS

Name: TMS
Brand: TargetMol
SKU: T3585
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3585Cas No. 24144-92-1

Alias 2,3',4,5'-Tetramethoxystilbene, (E)-2,3',4,5'-tetramethoxystilbene

TMS (2,3',4,5'-Tetramethoxystilbene) is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1).

TMS

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Purity: 99.73%

Catalog No. T3585Alias 2,3',4,5'-Tetramethoxystilbene, (E)-2,3',4,5'-tetramethoxystilbeneCas No. 24144-92-1

TMS (2,3',4,5'-Tetramethoxystilbene) is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1).

Pack Size	Price	Availability
5 mg	$47	In Stock
10 mg	$77	In Stock
25 mg	$153	In Stock
50 mg	$279	In Stock
100 mg	$416	In Stock
500 mg	$942	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock

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Batch Information

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Purity:99.73%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	TMS (2,3',4,5'-Tetramethoxystilbene) is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1).
Targets&IC50	CYP1A1:300 nM (IC50), CYP1A2:3.1 μM (IC50), CYP1B1:6 nM (IC50), CYP1B1:3 nM (Ki)
In vitro	Twenty-four hours after incubation with the 10 μM DOX in the presence and absence of 0.5 μM TMS, approximately 1.5 × 106 cells per six-well culture plate were collected in 100 μl lysis buffer (50 mM HEPES, 0.5 M sodium chloride, 1.5 mM magnesium chloride, 1 mM EDTA, 10% glycerol (v/v), 1% Triton X-100, and 5 μl/ml of protease inhibitor cocktail).
In vivo	Mice were administered 300 μg/kg of selective inhibitor of P450 1B1, TMS or its vehicle (dimethyl sulfoxide), i.p. every third day for the duration of the experimental period
Synonyms	2,3',4,5'-Tetramethoxystilbene, (E)-2,3',4,5'-tetramethoxystilbene

Chemical Properties

Molecular Weight	300.35
Formula	C₁₈H₂₀O₄
Cas No.	24144-92-1
Smiles	COc1ccc(\C=C\c2cc(OC)cc(OC)c2)c(OC)c1
Relative Density.	1.117 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (166.47 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3294 mL	16.6472 mL	33.2945 mL	166.4724 mL
5 mM	0.6659 mL	3.3294 mL	6.6589 mL	33.2945 mL
10 mM	0.3329 mL	1.6647 mL	3.3294 mL	16.6472 mL
20 mM	0.1665 mL	0.8324 mL	1.6647 mL	8.3236 mL
50 mM	0.0666 mL	0.3329 mL	0.6659 mL	3.3294 mL
100 mM	0.0333 mL	0.1665 mL	0.3329 mL	1.6647 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc