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Bucillamine

Name: Bucillamine
Brand: TargetMol
SKU: T21334
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21334Cas No. 65002-17-7

Alias Tiobutarit, Thiobutarit, SA96, DE-019, DE019, DE 019

Bucillamine (DE019) protects against Ischemia/reperfusion injury in high-risk organ transplants and inhibits the production of VEGF. Bucillamine is an orally active sulfhydryl donor and antioxidant with antirheumatic and antiangiogenic properties. Bucillamine can be used for studies about choroidal neovascularization and rheumatoid arthritis.

Bucillamine

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Purity: 99.47%

Catalog No. T21334Alias Tiobutarit, Thiobutarit, SA96, DE-019, DE019, DE 019Cas No. 65002-17-7

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$33	In Stock	In Stock
50 mg	$56	In Stock	In Stock
100 mg	$93	In Stock	In Stock
200 mg	$137	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.47%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Bucillamine (DE019) protects against Ischemia/reperfusion injury in high-risk organ transplants and inhibits the production of VEGF. Bucillamine is an orally active sulfhydryl donor and antioxidant with antirheumatic and antiangiogenic properties. Bucillamine can be used for studies about choroidal neovascularization and rheumatoid arthritis.
In vivo	In rats subjected to liver transplants, Bucillamine significantly enhances survival and protected against hepatic injury[2]. Subconjunctival injection of Bucillamine significantly reduces the leakage and size of experimental CNV in rats[3].
Synonyms	Tiobutarit, Thiobutarit, SA96, DE-019, DE019, DE 019

Chemical Properties

Molecular Weight	223.31
Formula	C₇H₁₃NO₃S₂
Cas No.	65002-17-7
Smiles	[C@@H](NC(C(C)(C)S)=O)(C(O)=O)CS
Relative Density.	1.289 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (111.95 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4781 mL	22.3904 mL	44.7808 mL	223.9040 mL
5 mM	0.8956 mL	4.4781 mL	8.9562 mL	44.7808 mL
10 mM	0.4478 mL	2.2390 mL	4.4781 mL	22.3904 mL
20 mM	0.2239 mL	1.1195 mL	2.2390 mL	11.1952 mL
50 mM	0.0896 mL	0.4478 mL	0.8956 mL	4.4781 mL
100 mM	0.0448 mL	0.2239 mL	0.4478 mL	2.2390 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc