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N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea

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Catalog No. T12156Cas No. 97627-24-2

N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea is an anticonvulsant agent, treatment of generalized tonic-clonic and partial seizures.

N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea

N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea

🥰Excellent
Purity: 99.83%
Catalog No. T12156Cas No. 97627-24-2
N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea is an anticonvulsant agent, treatment of generalized tonic-clonic and partial seizures.
Pack SizePriceAvailabilityQuantity
2 mg$31In Stock
5 mg$51In Stock
10 mg$86In Stock
25 mg$173In Stock
50 mg$278In Stock
100 mg$447In Stock
200 mg$619In Stock
1 mL x 10 mM (in DMSO)$56In Stock
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Purity:99.83%
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Product Introduction

Bioactivity
Description
N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea is an anticonvulsant agent, treatment of generalized tonic-clonic and partial seizures.
In vivo
N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea shows anticonvulsant activity at 30 mg/kg in the initial tests with no signs of ataxia until 300 mg/kg.?The activity seen with 30 mg/kg 37 is still present 4 h postdose.?Compound is effective against seizures induced by maximal electroshock but does not protect mice from clonic seizures produced by the convulsant pentylenetetrazol.?The overall pharmacological profile suggests that Compound would be of therapeutic use in the treatment of generalized tonic-clonic and partial seizures[1].
Chemical Properties
Molecular Weight261.71
FormulaC13H12ClN3O
Cas No.97627-24-2
SmilesCc1cccc(Cl)c1NC(=O)Nc1ccncc1
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 120 mg/mL (458.52 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (15.28 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.8210 mL19.1051 mL38.2102 mL191.0512 mL
5 mM0.7642 mL3.8210 mL7.6420 mL38.2102 mL
10 mM0.3821 mL1.9105 mL3.8210 mL19.1051 mL
20 mM0.1911 mL0.9553 mL1.9105 mL9.5526 mL
50 mM0.0764 mL0.3821 mL0.7642 mL3.8210 mL
100 mM0.0382 mL0.1911 mL0.3821 mL1.9105 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

N(2Chloro6methylphenyl)N'4pyridinylureaN-(2-Chloro-6-methylphenyl)-N'-4-pyridinylureaN (2 Chloro 6 methylphenyl) N' 4 pyridinylureaInhibitorinhibit
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