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Folic acid

Name: Folic acid
Brand: TargetMol
SKU: T0062
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0062Cas No. 59-30-3

Alias Vitamin M, Vitamin B9, Pteroylglutamic acid, Folate, Folacin

Folic acid is an orally active essential nutrient involved in the synthesis of DNA/RNA and the production and maintenance of new cells. It exhibits antidepressant-like effects and can reduce the risk of neural tube defects in newborns. Folate deficiency can cause megaloblastic anemia, macrocytic anemia, neural tube closure defects, tumors, and aging-related diseases. Folic acid is also commonly used in research on folate deficiency-related conditions and to induce acute kidney injury models.

Folic acid

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Purity: 99.27%

Catalog No. T0062Alias Vitamin M, Vitamin B9, Pteroylglutamic acid, Folate, FolacinCas No. 59-30-3

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$31	In Stock	In Stock
1 g	$38	In Stock	In Stock
2 g	$45	In Stock	In Stock
5 g	$58	-	In Stock
10 g	$71	-	In Stock
25 g	$98	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.27%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Folic acid is an orally active essential nutrient involved in the synthesis of DNA/RNA and the production and maintenance of new cells. It exhibits antidepressant-like effects and can reduce the risk of neural tube defects in newborns. Folate deficiency can cause megaloblastic anemia, macrocytic anemia, neural tube closure defects, tumors, and aging-related diseases. Folic acid is also commonly used in research on folate deficiency-related conditions and to induce acute kidney injury models.
Targets&IC50	FRα:0.0015 µg/mL, FRβ:0.0015 µg/mL
In vitro	METHODS: HUVEC cells were treated with Folic acid (2.5-100 µM) for 48 h. Cell proliferation was detected using xCELLigence RTCA real-time cell analyzer. RESULTS: Folic acid increased cell proliferation in the HUVEC cell line using a cytometric index to determine the EC50 dose of 50 µL.[1] METHODS: Neural tube explants were treated with Folic acid (90 µM) for 3 h and morphology was observed using microscopy. RESULTS: In the presence of Folic acid, cell migration from the neural tube explants was detected in 80% of the cultures within 2-3 h. The first cell to leave the initial explant was the first cell to leave the neural tube explant. The first cells leaving the initial explants were tightly organized neuroepithelial cells and the explants were firmly attached to the fibronectin layer. [2]
In vivo	METHODS: To investigate the role of Folic acid (1-100 mg/kg) in a behavioral model of depression, Swiss mice were administered Folic acid (1-100 mg/kg) in a single gavage dose and subjected to the forced swimming test (FST) and tail suspension test (TST). RESULTS: Oral administration of Folic acid reduced immobilization time in the FST (50-100 mg/kg) and TST (10-50 mg/kg). Folic acid produces antidepressant-like effects in the FST and TST. [3]
Cell Research	To determine the effect of FA supplementation on BRCA1 and BRCA2 mRNA expression, all cell lines were treated with 0, 25, 50, 75, or 100 nmol/L FA for 72 hours before harvesting in TRI Reagent according to the manufacturer’s instructions. (Only for Reference)
Synonyms	Vitamin M, Vitamin B9, Pteroylglutamic acid, Folate, Folacin

Chemical Properties

Molecular Weight	441.40
Formula	C₁₉H₁₉N₇O₆
Cas No.	59-30-3
Smiles	NC1=NC(O)=C2N=C(CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)C=NC2=N1
Relative Density.	1.68 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (56.64 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (5.66 mM), Suspension.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2655 mL	11.3276 mL	22.6552 mL	113.2759 mL
5 mM	0.4531 mL	2.2655 mL	4.5310 mL	22.6552 mL
10 mM	0.2266 mL	1.1328 mL	2.2655 mL	11.3276 mL
20 mM	0.1133 mL	0.5664 mL	1.1328 mL	5.6638 mL
50 mM	0.0453 mL	0.2266 mL	0.4531 mL	2.2655 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc