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Folic acid

Folic acid
Folic acid (Vitamin B9) is a vitamin B9 that is essential for the synthesis of DNA/RNA and for the production and maintenance of new cells. Folic acid deficiency can lead to anemia, neural tube closure defects, tumors, aging, and other diseases.
Catalog No. T0062Cas No. 59-30-3
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Purity:99.27%
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Folic acid

Catalog No. T0062Cas No. 59-30-3

Folic acid (Vitamin B9) is a vitamin B9 that is essential for the synthesis of DNA/RNA and for the production and maintenance of new cells. Folic acid deficiency can lead to anemia, neural tube closure defects, tumors, aging, and other diseases.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
500 mg$45In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Product Introduction

Bioactivity
Description
Folic acid (Vitamin B9) is a vitamin B9 that is essential for the synthesis of DNA/RNA and for the production and maintenance of new cells. Folic acid deficiency can lead to anemia, neural tube closure defects, tumors, aging, and other diseases.
In vitro
METHODS: HUVEC cells were treated with Folic acid (2.5-100 µM) for 48 h. Cell proliferation was detected using xCELLigence RTCA real-time cell analyzer.
RESULTS: Folic acid increased cell proliferation in the HUVEC cell line using a cytometric index to determine the EC50 dose of 50 µL.[1]
METHODS: Neural tube explants were treated with Folic acid (90 µM) for 3 h and morphology was observed using microscopy.
RESULTS: In the presence of Folic acid, cell migration from the neural tube explants was detected in 80% of the cultures within 2-3 h. The first cell to leave the initial explant was the first cell to leave the neural tube explant. The first cells leaving the initial explants were tightly organized neuroepithelial cells and the explants were firmly attached to the fibronectin layer. [2]
In vivo
METHODS: To investigate the role of Folic acid (1-100 mg/kg) in a behavioral model of depression, Swiss mice were administered Folic acid (1-100 mg/kg) in a single gavage dose and subjected to the forced swimming test (FST) and tail suspension test (TST).
RESULTS: Oral administration of Folic acid reduced immobilization time in the FST (50-100 mg/kg) and TST (10-50 mg/kg). Folic acid produces antidepressant-like effects in the FST and TST. [3]
Cell Research
To determine the effect of FA supplementation on BRCA1 and BRCA2 mRNA expression, all cell lines were treated with 0, 25, 50, 75, or 100 nmol/L FA for 72 hours before harvesting in TRI Reagent according to the manufacturer’s instructions. (Only for Reference)
AliasFolate, Vitamin B9, Pteroylglutamic acid, Vitamin M, Folacin
Chemical Properties
Molecular Weight441.4
FormulaC19H19N7O6
Cas No.59-30-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (5.66 mM), Suspension. Working solution is recommended to be prepared and used immediately.
DMSO: 25 mg/mL (56.63 mM), Sonication is recommended.
Solution Preparation Table
10% DMSO+40% PEG300+5% Tween 80+45% Saline/DMSO
1mg5mg10mg50mg
1 mM2.2655 mL11.3276 mL22.6552 mL113.2759 mL
5 mM0.4531 mL2.2655 mL4.5310 mL22.6552 mL
DMSO
1mg5mg10mg50mg
10 mM0.2266 mL1.1328 mL2.2655 mL11.3276 mL
20 mM0.1133 mL0.5664 mL1.1328 mL5.6638 mL
50 mM0.0453 mL0.2266 mL0.4531 mL2.2655 mL

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