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Dimetridazole

Name: Dimetridazole
Brand: TargetMol
SKU: T0874
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0874Cas No. 551-92-8

Alias 1,2-Dimethyl-5-nitroimidazole, 1, 2-Dimethyl-5-nitroimidazole

Dimetridazole (1, 2-Dimethyl-5-nitroimidazole) is a drug that combats protozoan infections. It is a nitroimidazole class drug. It has been banned by the Canadian government as a livestock feed additive.

Dimetridazole

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Purity: 99.88%

Catalog No. T0874Alias 1,2-Dimethyl-5-nitroimidazole, 1, 2-Dimethyl-5-nitroimidazoleCas No. 551-92-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$35	In Stock	-
5 g	$81	-	In Stock
10 g	$118	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Dimetridazole AI Summary

Dimetridazole demonstrates a broad spectrum of biological activities. It exhibits in vitro anti-trichomonal activity against Trichomonas foetus-Ortho strain-2 with an ED50 of 0.3 µg/ml and against Trichomonas vaginalis TVR87 with an IC50 of 708.0 nM. The compound shows mutagenic effects in Trichomonas foetus at 15.0% relative to Ronidazole and against Salmonella Typhimurium YG1042 and TA100. In terms of selectivity, it has a high specificity index of >2501.0, indicating greater selectivity toward Trichomonas vaginalis over human THP1 cells. For anticarcinogenic activity, Dimetridazole has a TD50 value of 120.46 µmol/Kg in rat models and a pTD50 value of 2.081, reflecting its potency in tumor inhibition. It also demonstrates the potential to inhibit the entry of the Ebola virus across various channels with AC50 values ranging from 562.3 nM to 44.67 µM. In combating SARS-CoV-2, the compound shows mixed antiviral results. It has a low inhibition index of 0.5596 in Vero E6 cells and a minor inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM concentration, with percentages of -2.64% and 0.02% respectively. Moreover, it inhibits the SARS-CoV-2 3CL-Pro protease by 7.611% at 20 µM. Finally, the compound's enzymatic activity against human HDAC6 shows varied inhibition: 7.7% with a commercial peptide substrate and -7.43% with a custom peptide substrate. Dimetridazole has a safety index of 8.9, suggesting a relative margin between effective and toxic doses across its various biological activities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dimetridazole (1, 2-Dimethyl-5-nitroimidazole) is a drug that combats protozoan infections. It is a nitroimidazole class drug. It has been banned by the Canadian government as a livestock feed additive.
Synonyms	1,2-Dimethyl-5-nitroimidazole, 1, 2-Dimethyl-5-nitroimidazole

Chemical Properties

Molecular Weight	141.13
Formula	C₅H₇N₃O₂
Cas No.	551-92-8
Smiles	N(=O)(=O)C=1N(C)C(C)=NC1
Relative Density.	1.36 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (177.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (14.17 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.0857 mL	35.4283 mL	70.8567 mL	354.2833 mL
5 mM	1.4171 mL	7.0857 mL	14.1713 mL	70.8567 mL
10 mM	0.7086 mL	3.5428 mL	7.0857 mL	35.4283 mL
20 mM	0.3543 mL	1.7714 mL	3.5428 mL	17.7142 mL
50 mM	0.1417 mL	0.7086 mL	1.4171 mL	7.0857 mL
100 mM	0.0709 mL	0.3543 mL	0.7086 mL	3.5428 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc