Pritelivir mesylate

Name: Pritelivir mesylate
Brand: TargetMol
SKU: T16576
Rating: 4.5 (1 reviews)

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Catalog No. T16576Cas No. 1428333-96-3

Alias BAY 57-1293 mesylate, AIC316 mesylate

Pritelivir mesylate is active against herpes simplex virus types 1 and 2 (IC50: 0.02 μM against HSV1-2). Pritelivir mesylate is an inhibitor of the viral helicase-primase complex. Pritelivir mesylate shows antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection.

Pritelivir mesylate

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Catalog No. T16576Alias BAY 57-1293 mesylate, AIC316 mesylateCas No. 1428333-96-3

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Product Introduction

Bioactivity

Description	Pritelivir mesylate is active against herpes simplex virus types 1 and 2 (IC50: 0.02 μM against HSV1-2). Pritelivir mesylate is an inhibitor of the viral helicase-primase complex. Pritelivir mesylate shows antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection.
Targets&IC50	HSV12:0.02 μM
In vivo	Pritelivir mesylate is the first in a class of antiviral agents that inhibit HSV replication by targeting the viral helicase–primase enzyme complex. Pritelivir mesylate has potent and resistance-breaking antiviral efficacy with potential for the treatment of potentially life-threatening HSV type 1 and 2 infections, including herpes simplex encephalitis. Pritelivir mesylate (0.03-45 mg/kg) significantly increases survival. Pritelivir mesylate (0.3-30 mg/kg) reduces mortality against HSV-1, E-377. Combination therapies of Pritelivir mesylate at 0.1 or 0.3 mg/kg/dose with Acyclovir (10 mg/kg/dose) are protective when compared to the vehicle treated group against HSV-2, strain MS [2][3].
Synonyms	BAY 57-1293 mesylate, AIC316 mesylate

Chemical Properties

Molecular Weight	498.6
Formula	C₁₉H₂₂N₄O₆S₃
Cas No.	1428333-96-3
Smiles	CS(O)(=O)=O.CN(C(=O)Cc1ccc(cc1)-c1ccccn1)c1nc(C)c(s1)S(N)(=O)=O
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc