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TOPRelated productsBioactivityChemical infoStorage&SolubilityCalculator

[Leu5]-Enkephalin acetate(58822-25-6 free base)

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Catalog No. T7173L
Alias Leu-enkephalin, Leucyl-enkephalin, Leucine enkephalin

[Leu5]-Enkephalin acetate(58822-25-6 free base) is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively)

[Leu5]-Enkephalin acetate(58822-25-6 free base)
Other Forms of [Leu5]-Enkephalin acetate(58822-25-6 free base):

[Leu5]-Enkephalin acetate(58822-25-6 free base)

🥰Excellent
Purity: 99.28%
Catalog No. T7173LAlias Leu-enkephalin, Leucyl-enkephalin, Leucine enkephalin
[Leu5]-Enkephalin acetate(58822-25-6 free base) is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively)
Pack SizePriceAvailabilityQuantity
10 mg$51In Stock
25 mg$101In Stock
50 mg$153In Stock
100 mg$230In Stock
200 mg$345In Stock
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Purity:99.28%
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COA HPLC MS

Product Introduction

Bioactivity
Description
[Leu5]-Enkephalin acetate(58822-25-6 free base) is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively)
Targets&IC50
μ opioid receptor:3.4 nM(ki), δ opioid receptor:4.0 nM(ki)
In vivo
[Leu5]-Enkephalin is found in the brain, the brainstem, and the spinal cord as well as in the peripheral nervous system. Leu-Enkephalin (1 mg/kg) decreases the visceromotor response to colon distension in a mouse model of visceral pain induced by colorectal distension[1].
SynonymsLeu-enkephalin, Leucyl-enkephalin, Leucine enkephalin
Chemical Properties
Molecular Weight615.68
FormulaC30H41N5O9
SmilesCC(C)C[C@@H](C(O)=O)NC([C@@H](NC(CNC(CNC([C@@H](N)CC1=CC=C(C=C1)O)=O)=O)=O)CC2=CC=CC=C2)=O.CC(O)=O
Relative Density.1.31g/cm3
SequenceH-Tyr-Gly-Gly-Phe-Leu-OH
Sequence ShortYGGFL
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

μ-opioid receptorδ-opioid receptorOpioidReceptorOpioid ReceptorEndogenousMetaboliteEndogenous Metabolite[Leu5]-Enkephalin acetate(58822-25-6 free base)[Leu-5]-Enkephalin acetate(58822-25-6 free base)[Leu5]Enkephalin acetate(58822256 free base)[Leu5] Enkephalin acetate(58822 25 6 free base)
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