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SSAA09E2

Name: SSAA09E2
Brand: TargetMol
SKU: T9109
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9109Cas No. 883944-52-3

SSAA09E2 is a new SARS-CoV replication inhibitor, acting by blocking early interactions of SARS-S with the receptor for SARS-CoV, Angiotensin Converting Enzyme-2 (ACE2).

SSAA09E2

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Purity: 98.71%

Catalog No. T9109Cas No. 883944-52-3

SSAA09E2 is a new SARS-CoV replication inhibitor, acting by blocking early interactions of SARS-S with the receptor for SARS-CoV, Angiotensin Converting Enzyme-2 (ACE2).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$33	-	In Stock
5 mg	$73	-	In Stock
10 mg	$118	-	In Stock
25 mg	$273	-	In Stock
50 mg	$403	-	In Stock
100 mg	$573	-	In Stock
200 mg	$778	-	In Stock
1 mL x 10 mM (in DMSO)	$80	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.71%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

SSAA09E2 AI Summary

SSAA09E2 shows potential antiviral activity by inhibiting SARS-COV pseudotyped virus infection in HEK293T cells, with an IC50 value of 3100.0 nM. It specifically inhibits the binding of the SARS-COV2 spike protein receptor-binding domain (S-RBD) to human ACE2, as evidenced by the NanoLuc luciferase assay. Furthermore, it exhibits a favorable safety profile with no significant cytotoxicity against human HEK293T cells, demonstrated by a CC50 value greater than 100000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

SSAA09E2 is a new SARS-CoV replication inhibitor, acting by blocking early interactions of SARS-S with the receptor for SARS-CoV, Angiotensin Converting Enzyme-2 (ACE2).

Chemical Properties

Molecular Weight	300.36
Formula	C₁₆H₂₀N₄O₂
Cas No.	883944-52-3
Smiles	CN1CCN(CC1)c1ccc(CNC(=O)c2ccno2)cc1
Relative Density.	1.202 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 230 mg/mL (765.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (10.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3293 mL	16.6467 mL	33.2934 mL	166.4669 mL
5 mM	0.6659 mL	3.3293 mL	6.6587 mL	33.2934 mL
10 mM	0.3329 mL	1.6647 mL	3.3293 mL	16.6467 mL
20 mM	0.1665 mL	0.8323 mL	1.6647 mL	8.3233 mL
50 mM	0.0666 mL	0.3329 mL	0.6659 mL	3.3293 mL
100 mM	0.0333 mL	0.1665 mL	0.3329 mL	1.6647 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc