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Neurotensin Receptor

The neurotensin receptors are transmembrane receptors that bind the neurotransmitter neurotensin. Two of the receptors encoded by the NTSR1 and NTSR2 genes contain seven transmembrane helices and are G protein coupled. The third receptor has a single transmembrane domain and is encoded by the SORT1 gene.

  • [Lys8, Lys9]-Neurotensin (8-13) acetate
    T38807L
    [Lys8, Lys9]-Neurotensin (8-13) acetate, a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with Ki values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively[1].
    • $148
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    TargetMol | Inhibitor Sale
  • Kinetensin acetate(103131-69-7 free base)
    TP1116L
    Kinetensin acetate(103131-69-7 free base) is isolated from pepsin-treated human plasma. Kinetensin acetate(103131-69-7 free base) is a neurotensin-like peptide.
    • $96
    In Stock
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  • UFP 803 acetate
    TP2104L
    UFP 803 acetate is a potent ligand of urotensin-II (UT) receptor. UFP-803 displays the activity of a lower residual agonist.
    • $339
    In Stock
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  • Urantide acetate(669089-53-6 free base)
    TP2106L
    Urantide acetate is a selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-ind
    • $115
    In Stock
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  • Substance P 1-9 aceate
    TP1819L
    Substance P 1-9 aceate is nonapeptide, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder.
    • $59
    In Stock
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  • NTRC-844
    T282171811503-67-9In house
    NTRC-844 is a selective rat neurotensin receptor type 2 (NTS2) antagonist that shows analgesic activity in animal models of pain.
    • $350
    In Stock
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  • (±)-AC 7954 hydrochloride
    T22476477313-09-0
    (±)-AC 7954 hydrochloride is a urotensin-II (UT) receptor activator.
    • $82
    In Stock
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  • Neurotensin(8-13) 3TFA(60482-95-3(free base))
    T7617L2952825-79-3
    Neurotensin(8-13) 3TFA is Neurotensin (NT) fragment. Neurotensin(8-13) 3TFA results in a decrease in cell-surface NT1 receptors (NTR1) density.
    • $53
    In Stock
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  • Meclinertant
    T16034146362-70-1In house
    Meclinertant (SR 48692) is a neurotensin receptor-1 (NT1) antagonist that blocks neurotensin-induced excitation and can be used to study neurological disorders.
    • $78 TargetMol
    In Stock
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  • SBI-553
    T168601849603-72-0
    SBI-553 is an effective and brain penetrant NTR1 allosteric modulator (EC50: 0.34 μM).
    • $97
    In Stock
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    TargetMol | Citations Cited
  • ML314
    TQ00751448895-09-7
    ML314 is a brain-permeable nonpeptide β-inhibin-biased neurotensin NTR1 receptor agonist (EC50: 1.9 μM), a biased neurotensin receptor ligand for methamphetamine abuse that inhibits NTR2 and GPR35.
      7-10 days
      Inquiry
    • Neurotensin
      TP131039379-15-2
      Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system.
      • $52
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    • Neurotensin(8-13)
      T761760482-95-3
      Neurotensin(8-13) is Neurotensin (NT) fragment, Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density.
      • $46
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    • SB-657510
      T12848474960-44-6
      SB-657510 is a urotensin II (UII) receptor (UT) antagonist. The Ki values of UT for human, monkey, cat, rat and mouse were 61, 17, 30, 65 and 56 nM, respectively. SB-657510 plays an anti-inflammatory role by inhibiting UII-induced inflammatory mediators, such as adhesion molecules, in human vascular endothelial cells and upregulation of cytokines and tissue factors. SB 657510 has a therapeutic effect on diabetes-related atherosclerotic disease in diabetic mouse models.
      • $75
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    • hNTS1R agonist-1
      T78954
      Compound 10, an hNTS1R agonist-1, acts as a full agonist with a strong affinity for hNTS1R (K i: 6.9 nM), showing the ability to cross the blood-brain barrier (BBB). It not only enhances motor function but also improves memory in a mouse model of Parkinson's disease (PD). Additionally, this compound is an analog of Neurotensin(8-13) and demonstrates neuroprotective properties [1].
      • Inquiry Price
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    • SORT-PGRN interaction inhibitor 3
      T791062691846-87-2
      SORT-PGRN Interaction Inhibitor 3 (Compound 13), with an IC50 value of 0.17 μM, acts as an inhibitor of the SORT-PGRN interaction, and is utilized in the study of neurodegenerative diseases [1].
      • $1,520
      Backorder
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    • BVFP
      T79105357158-20-4
      BVFP exhibits affinity for the PGRN 588–593 peptide through binding with a dissociation constant (Kd) of 20 μM and is capable of disrupting the interaction between PGRN and SORT1. Moreover, BVFP inhibits the SORT1-mediated endocytosis of recombinant PGRN (rPGRN) [1].
      • Inquiry Price
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    • AF38469
      TQ00861531634-31-7
      AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM).
      • $107
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    • SB 611812
      T23323345892-71-9
      SB 611812 is an antagonist of urotensin-II (UT) and can be used in studies about the treatment of cardiovascular disease.
      • $38
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    • SORT-PGRN interaction inhibitor 1
      T9044100957-85-5
      SORT-PGRN interaction inhibitor 1 is a potent sortilin-progranulin interaction inhibitor(IC50 of 2 μM).
      • $29
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    • Latozinemab
      T77053
      Latozinemab (AL001) is a potent and selective recombinant humanized monoclonal antibody against Sortilin.Latozinemab has a high affinity for Sortilin and interrupts the interaction between the granule protein precursor (PGRN) and the Sortilin receptor.Latozinemab can be used to study of dementia and Alzheimer's disease.
      • $473
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    • SR 142948
      T23386184162-64-9
      SR 142948 is a neurotensin (NT) receptor antagonist.
      • $925
      35 days
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