Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Neurotensin Receptor

The neurotensin receptors are transmembrane receptors that bind the neurotransmitter neurotensin. Two of the receptors encoded by the NTSR1 and NTSR2 genes contain seven transmembrane helices and are G protein coupled. The third receptor has a single transmembrane domain and is encoded by the SORT1 gene.

Meclinertant
T16034146362-70-1In house
Meclinertant (SR 48692) is a neurotensin receptor-1 (NT1) antagonist that blocks neurotensin-induced excitation and can be used to study neurological disorders.
  • $78 TargetMol
In Stock
Size
QTY
TargetMol | Inhibitor Hot
SBI-553
T168601849603-72-0
SBI-553 is an effective and brain penetrant NTR1 allosteric modulator (EC50: 0.34 μM).
  • $97
In Stock
Size
QTY
TargetMol | Citations Cited
AF38469
TQ00861531634-31-7
AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM).
  • $107
In Stock
Size
QTY
Neurotensin
TP131039379-15-2
Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system.
  • $52
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Kinetensin acetate(103131-69-7 free base)
TP1116L
Kinetensin acetate(103131-69-7 free base) is isolated from pepsin-treated human plasma. Kinetensin acetate(103131-69-7 free base) is a neurotensin-like peptide.
  • $96
In Stock
Size
QTY
Neurotensin(8-13)
T761760482-95-3
Neurotensin(8-13) is Neurotensin (NT) fragment, Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density.
  • $178
In Stock
Size
QTY
Urantide acetate(669089-53-6 free base)
TP2106L
Urantide acetate is a selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-ind
  • $115
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Neurotensin(8-13) 3TFA(60482-95-3(free base))
T7617L2952825-79-3
Neurotensin(8-13) 3TFA is Neurotensin (NT) fragment. Neurotensin(8-13) 3TFA results in a decrease in cell-surface NT1 receptors (NTR1) density.
  • $32
In Stock
Size
QTY
TargetMol | Inhibitor Sale
SORT-PGRN interaction inhibitor 1
T9044100957-85-5
SORT-PGRN interaction inhibitor 1 is a potent inhibitor of the sortilin-progranulin interaction, with an IC50 of 2 μM.
  • $29
In Stock
Size
QTY
TargetMol | Inhibitor Sale
UFP 803 acetate
TP2104L
UFP 803 acetate is a potent ligand of urotensin-II (UT) receptor. UFP-803 displays the activity of a lower residual agonist.
  • $339
In Stock
Size
QTY
Substance P 1-9 aceate
TP1819L
Substance P 1-9 aceate is nonapeptide, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder.
  • $59
In Stock
Size
QTY
NTRC-844
T282171811503-67-9In house
NTRC-844 is a selective rat neurotensin receptor type 2 (NTS2) antagonist that shows analgesic activity in animal models of pain.
    Inquiry
    [Lys8, Lys9]-Neurotensin (8-13) acetate
    T38807L
    [Lys8, Lys9]-Neurotensin (8-13) acetate, a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with Ki values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively[1].
    • $89
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
    (±)-AC 7954 hydrochloride
    T22476477313-09-0
    (±)-AC 7954 hydrochloride is a urotensin-II (UT) receptor activator.
    • $82
    In Stock
    Size
    QTY
    SB-657510
    T12848474960-44-6
    SB-657510 is a urotensin II (UII) receptor (UT) antagonist. The Ki values of UT for human, monkey, cat, rat and mouse were 61, 17, 30, 65 and 56 nM, respectively. SB-657510 plays an anti-inflammatory role by inhibiting UII-induced inflammatory mediators, such as adhesion molecules, in human vascular endothelial cells and upregulation of cytokines and tissue factors. SB 657510 has a therapeutic effect on diabetes-related atherosclerotic disease in diabetic mouse models.
    • $45
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
    SB 611812
    T23323345892-71-9
    SB 611812 is an antagonist of urotensin-II (UT) and can be used in studies about the treatment of cardiovascular disease.
    • $38
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
    Latozinemab
    T77053
    Latozinemab (AL001) is a potent and selective recombinant humanized monoclonal antibody against Sortilin.Latozinemab has a high affinity for Sortilin and interrupts the interaction between the granule protein precursor (PGRN) and the Sortilin receptor.Latozinemab can be used to study of dementia and Alzheimer's disease.
    • $263
    In Stock
    Size
    QTY
    ML314
    TQ00751448895-09-7
    ML314 is a brain-permeable nonpeptide β-inhibin-biased neurotensin NTR1 receptor agonist (EC50: 1.9 μM), a biased neurotensin receptor ligand for methamphetamine abuse that inhibits NTR2 and GPR35.
      Inquiry
      hNTS1R agonist-1
      T78954
      Compound 10, an hNTS1R agonist-1, acts as a full agonist with a strong affinity for hNTS1R (K i: 6.9 nM), showing the ability to cross the blood-brain barrier (BBB). It not only enhances motor function but also improves memory in a mouse model of Parkinson's disease (PD). Additionally, this compound is an analog of Neurotensin(8-13) and demonstrates neuroprotective properties [1].
      • Inquiry Price
      Size
      QTY
      SORT-PGRN interaction inhibitor 3
      T791062691846-87-2
      SORT-PGRN Interaction Inhibitor 3 (Compound 13), with an IC50 value of 0.17 μM, acts as an inhibitor of the SORT-PGRN interaction, and is utilized in the study of neurodegenerative diseases [1].
      • $1,520
      6-8 weeks
      Size
      QTY
      BVFP
      T79105357158-20-4
      BVFP exhibits affinity for the PGRN 588–593 peptide through binding with a dissociation constant (Kd) of 20 μM and is capable of disrupting the interaction between PGRN and SORT1. Moreover, BVFP inhibits the SORT1-mediated endocytosis of recombinant PGRN (rPGRN) [1].
      • Inquiry Price
      8-10 weeks
      Size
      QTY
      SR 142948
      T23386184162-64-9
      SR 142948 is a neurotensin (NT) receptor antagonist.
      • $925
      35 days
      Size
      QTY