PHS Protein, Human, Recombinant (His)

Catalog No. TMPJ-01043 Copy Product Info

Pterin-4-α-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4-α-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterins and accelerate the formation of Quinonoid-BH2. Furthermore, PCBD1 regulates the homodimerization of the transcription factor Hepatocyte Nuclear Factor 1 (HNF1) and enhances its transcriptional activity. Defects in PCBD1 are the cause of BH4-Deficient Hyperphenylalaninemia Type D (HPABH4D). HPABH4D is characterized by the excretion of 7-substituted Pterins in the urine of affected patients.

PHS Protein, Human, Recombinant (His)

Catalog No. TMPJ-01043

Copy Product Info

Pack Size	Price	USA Stock	Global Stock
5 μg	$112	2-4 weeks	2-4 weeks
10 μg	$183	2-4 weeks	2-4 weeks
20 μg	$292	2-4 weeks	2-4 weeks
50 μg	$545	2-4 weeks	2-4 weeks
100 μg	$792	2-4 weeks	2-4 weeks
200 μg	$1,150	2-4 weeks	2-4 weeks
500 μg	$1,900	2-4 weeks	2-4 weeks
1 mg	$2,730	2-4 weeks	2-4 weeks

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Pterin-4-α-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4-α-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterins and accelerate the formation of Quinonoid-BH2. Furthermore, PCBD1 regulates the homodimerization of the transcription factor Hepatocyte Nuclear Factor 1 (HNF1) and enhances its transcriptional activity. Defects in PCBD1 are the cause of BH4-Deficient Hyperphenylalaninemia Type D (HPABH4D). HPABH4D is characterized by the excretion of 7-substituted Pterins in the urine of affected patients.
Species	Human
Expression System	E. coli
Tag	N-6xHis
Accession Number	P61457
Synonyms	Pterin-4-α-Carbinolamine Dehydratase,Pterin-4-Alpha-Carbinolamine Dehydratase,Pterin Carbinolami,PHS,Phenylalanine Hydroxylase-Stimulating Protein,Dimerization Cofactor of HNF1,Dimerization Cofactor of Hepatocyte Nuclear Factor 1-α,Dimerization Cofactor of Hepatocyte Nuclear Factor 1-Alpha,DCoH,4-α-Hydroxy-Tetrahydropterin Dehydratase,4-Alpha-Hydroxy-Tetrahydropterin Dehydratase
Amino Acid	Ala2-Thr104
Construction	Ala2-Thr104
Molecular Weight	14 KDa (reducing condition)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, pH 8.0.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Proteins are shipped with blue ice.
Research Background	Pterin-4-α-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4-α-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterins and accelerate the formation of Quinonoid-BH2. Furthermore, PCBD1 regulates the homodimerization of the transcription factor Hepatocyte Nuclear Factor 1 (HNF1) and enhances its transcriptional activity. Defects in PCBD1 are the cause of BH4-Deficient Hyperphenylalaninemia Type D (HPABH4D). HPABH4D is characterized by the excretion of 7-substituted Pterins in the urine of affected patients.

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Keywords

Pterin-4-a-Carbinolamine Dehydratase 4-a-Hydroxy-Tetrahydropterin Dehydratase