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PHS Protein, Human, Recombinant (His)

Catalog No. TMPJ-01043
Synonyms: 4-Alpha-Hydroxy-Tetrahydropterin Dehydratase, Pterin-4-α-Carbinolamine Dehydratase, Phenylalanine Hydroxylase-Stimulating Protein, Dimerization Cofactor of Hepatocyte Nuclear Factor 1-Alpha, PHS, Dimerization Cofactor of HNF1, Dimerization Cofactor of Hepatocyte Nuclear Factor 1-α, 4-α-Hydroxy-Tetrahydropterin Dehydratase, DCoH, Pterin Carbinolami, Pterin-4-Alpha-Carbinolamine Dehydratase

Pterin-4-α-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4-α-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterins and accelerate the formation of Quinonoid-BH2. Furthermore, PCBD1 regulates the homodimerization of the transcription factor Hepatocyte Nuclear Factor 1 (HNF1) and enhances its transcriptional activity. Defects in PCBD1 are the cause of BH4-Deficient Hyperphenylalaninemia Type D (HPABH4D). HPABH4D is characterized by the excretion of 7-substituted Pterins in the urine of affected patients.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
PHS Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 184.00
50 μg 5 days $ 545.00
500 μg 5 days $ 1,900.00
1 mg 5 days $ 2,730.00
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Biological Description
Technical Params
Product Properties
Description Pterin-4-α-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4-α-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterins and accelerate the formation of Quinonoid-BH2. Furthermore, PCBD1 regulates the homodimerization of the transcription factor Hepatocyte Nuclear Factor 1 (HNF1) and enhances its transcriptional activity. Defects in PCBD1 are the cause of BH4-Deficient Hyperphenylalaninemia Type D (HPABH4D). HPABH4D is characterized by the excretion of 7-substituted Pterins in the urine of affected patients.
Species Human
Expression System E. coli
Tag N-6His
Accession Number P61457
Synonyms 4-Alpha-Hydroxy-Tetrahydropterin Dehydratase, Pterin-4-α-Carbinolamine Dehydratase, Phenylalanine Hydroxylase-Stimulating Protein, Dimerization Cofactor of Hepatocyte Nuclear Factor 1-Alpha, PHS, Dimerization Cofactor of HNF1, Dimerization Cofactor of Hepatocyte Nuclear Factor 1-α, 4-α-Hydroxy-Tetrahydropterin Dehydratase, DCoH, Pterin Carbinolami, Pterin-4-Alpha-Carbinolamine Dehydratase
Amino Acid Ala2-Thr104
Construction Recombinant Human Pterin-4-alpha-Carbinolamine Dehydratase is produced by our E.coli expression system and the target gene encoding Ala2-Thr104 is expressed with a 6His tag at the N-terminus.
Molecular Weight 14 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, pH 8.0.
Stability & Storage

Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
Shipping

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Research Background Pterin-4-α-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4-α-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterins and accelerate the formation of Quinonoid-BH2. Furthermore, PCBD1 regulates the homodimerization of the transcription factor Hepatocyte Nuclear Factor 1 (HNF1) and enhances its transcriptional activity. Defects in PCBD1 are the cause of BH4-Deficient Hyperphenylalaninemia Type D (HPABH4D). HPABH4D is characterized by the excretion of 7-substituted Pterins in the urine of affected patients.

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Keywords

PHS Protein, Human, Recombinant (His) 4-Alpha-Hydroxy-Tetrahydropterin Dehydratase Pterin-4-α-Carbinolamine Dehydratase Phenylalanine Hydroxylase-Stimulating Protein Dimerization Cofactor of Hepatocyte Nuclear Factor 1-Alpha PHS Dimerization Cofactor of HNF1 Dimerization Cofactor of Hepatocyte Nuclear Factor 1-α 4-α-Hydroxy-Tetrahydropterin Dehydratase 4-a-Hydroxy-Tetrahydropterin Dehydratase DCoH Pterin-4-a-Carbinolamine Dehydratase Pterin Carbinolami Pterin-4-Alpha-Carbinolamine Dehydratase recombinant recombinant-proteins proteins protein

 

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