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GSTO1-IN-4
Catalog No. T213600 Copy Product Info
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GSTO1-IN-4 is a selective and potent inhibitor of GSTO1-1, exhibiting an IC50 of 0.04 μM and a KI of 0.16 μM. It has weaker inhibitory effects on GSTO2-2, GSTA1-1, and GSTP1-1. GSTO1-IN-4 alleviates inflammation in mice and significantly enhances the cytotoxicity of Cisplatin, making it useful for research in inflammation and breast cancer.
GSTO1-IN-4
Copy Product Info🥰Excellent
Catalog No. T213600
GSTO1-IN-4 is a selective and potent inhibitor of GSTO1-1, exhibiting an IC50 of 0.04 μM and a KI of 0.16 μM. It has weaker inhibitory effects on GSTO2-2, GSTA1-1, and GSTP1-1. GSTO1-IN-4 alleviates inflammation in mice and significantly enhances the cytotoxicity of Cisplatin, making it useful for research in inflammation and breast cancer.
GSTO1-IN-4
Cas No. 158890-33-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
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Storage & Solubility Information
| Description | GSTO1-IN-4 is a selective and potent inhibitor of GSTO1-1, exhibiting an IC50 of 0.04 μM and a KI of 0.16 μM. It has weaker inhibitory effects on GSTO2-2, GSTA1-1, and GSTP1-1. GSTO1-IN-4 alleviates inflammation in mice and significantly enhances the cytotoxicity of Cisplatin, making it useful for research in inflammation and breast cancer. |
| In vitro | GSTO1-IN-4 is an effective inhibitor of GSTO1-1 activity within BMDM cells, attenuating the activation of the NLRP3 inflammasome and the release of IL-1β. It demonstrates high selectivity for GSTO1-1 at a concentration of 10 μM, while showing lower inhibition on GSTA1-1 and GSTP1-1. At concentrations of 5-50 μM over 24 hours, GSTO1-IN-4 exhibits low cytotoxicity towards MDA-MB 231 cells at 5 μM (6.3%) and 10 μM (13.9%), but significantly increased cytotoxicity is observed at 50 μM (74.3%). |
| In vivo | GSTO1-IN-4 (50 mg/kg, administered intraperitoneally, single dose) effectively counteracts inflammation induced by Lipopolysaccharides (LPS) in mice. |
| Molecular Weight | 279.81 |
| Formula | C16H22ClNO |
| Cas No. | 158890-33-6 |
| Smiles | O=C(N1CCC(CC1)CCCC=2C=CC=CC2)CCl |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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