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CT-179

Name: CT-179
Brand: TargetMol
SKU: T70007
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: CT179) Copy Product Info

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Synonyms: CT179

Catalog No. T70007 Copy Product Info

Purity: 98.67%

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CT-179 is a potent and selective inhibitor of oligodendrocyte transcription factor 2 (OLIG2), reduces tumor cell proliferation and induces apoptosis, and enhances efficacy when used in combination with radiotherapy and other agents, showing potential in the treatment of medulloblastoma and glioblastoma.

Cas No. 1996636-69-1

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Pack Size	Price	USA Stock	Global Stock
1 mg	$48	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$179	In Stock	In Stock
25 mg	$328	In Stock	In Stock
50 mg	$538	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$126	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.67%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	CT-179 is a potent and selective inhibitor of oligodendrocyte transcription factor 2 (OLIG2), reduces tumor cell proliferation and induces apoptosis, and enhances efficacy when used in combination with radiotherapy and other agents, showing potential in the treatment of medulloblastoma and glioblastoma.
In vitro	Methods: Daoy, UW228, and Med-813 MB cells were treated with CT-179 (0.01-10 μM, 7 days), and cell viability was determined by MTT assay. Results: CT-179 showed activity in all three cell lines, with IC50 values of 143.6 nM, 285.4 nM, and 985.2 nM, respectively. [1]
In vivo	Methods: CT-179 (50 mg/kg, ip, twice weekly for 2 weeks) was combined with RT (8 Gy, 2 Gy fractions) to treat immunocompromised NOD rag γ (NRG) mice implanted with orthotopic Daoy-luci (SHH-MB) to investigate whether it exhibits similar antitumor activity against human MB in vivo. Results: Animals treated with CT-179 + RT had significantly slower progression and significantly delayed tumor growth in the brain and spinal cord; CT-179 combined with RT significantly prolonged EFS. [1]
Synonyms	CT179

Chemical Properties

Molecular Weight	397.3
Formula	C₁₇H₂₂Cl₂N₆O
Cas No.	1996636-69-1
Smiles	CN(C)CCCNc1cc(C)nc(NC(=O)Nc2ccc(Cl)c(Cl)c2)n1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5.19 mg/mL (13.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 0.52 mg/mL (1.31 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5170 mL	12.5849 mL	25.1699 mL	125.8495 mL
5 mM	0.5034 mL	2.5170 mL	5.0340 mL	25.1699 mL
10 mM	0.2517 mL	1.2585 mL	2.5170 mL	12.5849 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc