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ADAMTS-5 Inhibitor

Name: ADAMTS-5 Inhibitor
Brand: TargetMol
SKU: T14124
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14124Cas No. 929634-33-3

ADAMTS-5 Inhibitor is an inhibitor of ADAMTS-5 with an IC50 of 1.1 µM and can be used in studies about cartilage destruction in arthritis.

ADAMTS-5 Inhibitor

🥰Excellent

Purity: 99.66%

Catalog No. T14124Cas No. 929634-33-3

ADAMTS-5 Inhibitor is an inhibitor of ADAMTS-5 with an IC50 of 1.1 µM and can be used in studies about cartilage destruction in arthritis.

Pack Size	Price	Availability
1 mg	$40	In Stock
5 mg	$89	In Stock
10 mg	$130	In Stock
25 mg	$215	In Stock
50 mg	$320	In Stock
100 mg	$461	In Stock
200 mg	$645	In Stock
1 mL x 10 mM (in DMSO)	$103	In Stock

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Purity:99.66%

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Product Introduction

Bioactivity

Description

ADAMTS-5 Inhibitor is an inhibitor of ADAMTS-5 with an IC50 of 1.1 µM and can be used in studies about cartilage destruction in arthritis.

Chemical Properties

Molecular Weight	449.92
Formula	C₁₆H₁₁ClF₃N₃OS₃
Cas No.	929634-33-3
Smiles	Cn1nc(c(\C=C2/SC(=S)NC2=O)c1SCc1ccc(Cl)cc1)C(F)(F)F
Relative Density.	1.59±0.1 g/cm3 (20 °C, 760 mmHg)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 74.7 mg/mL (166 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2226 mL	11.1131 mL	22.2262 mL	111.1309 mL
5 mM	0.4445 mL	2.2226 mL	4.4452 mL	22.2262 mL
10 mM	0.2223 mL	1.1113 mL	2.2226 mL	11.1131 mL
20 mM	0.1111 mL	0.5557 mL	1.1113 mL	5.5565 mL
50 mM	0.0445 mL	0.2223 mL	0.4445 mL	2.2226 mL
100 mM	0.0222 mL	0.1111 mL	0.2223 mL	1.1113 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc