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Anti-ITGAX Antibody (6V627) is a Mouse antibody targeting ITGAX. Anti-ITGAX Antibody (6V627) can be used in WB,IP,IF,IHC-P.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $296 | 7-10 days | |
100 μL | $498 | 7-10 days |
Description | Anti-ITGAX Antibody (6V627) is a Mouse antibody targeting ITGAX. Anti-ITGAX Antibody (6V627) can be used in WB,IP,IF,IHC-P. |
Synonyms | SLEB6, leukocyte adhesion receptor p150, 95, leukocyte adhesion glycoprotein p150, 95 alpha chain, ITGAX, ITAX, integrin aX, integrin alpha-X precursor, Integrin alpha-X, complement receptor 4, CD11C(p150) alpha polypeptide, CD11 antigen-like family member C |
Reactivity | Human |
Verified Activity | 1. Western blot analysis of Integrin αX expression in non-transfected 293T (A), human Integrin αX transfected 293T (B) and HL-60 (C) whole cell. 2. Western blot analysis of Integrin αX expression in AML-193 whole cell lysate. |
Application | |
Recommended Dose | WB: 1:100-10000; IHC-P: 1:50-500; IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | Hybridoma Monoclonal Antibody |
Purification | ProA affinity purified |
Appearance | Liquid |
Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
Research Background | Integrin ?X (CD11C, leukocyte surface antigen p150,95, CR4, Axb2) is a type 1 transmembrane protein that traditionally combines with ∫2 chain to form a leukocyte-specific integrin known as inactivated-C3b (iC3b) receptor 4 (CR4). Integrin ?X/∫2 shares similar properties of the ?M/∫2 integrin in mediating adherence of neutrophils and monocytes to stimulated endothelial cells, and in phagocytosis of complement coated particles. Abnormal expression of Integrin ?X is characteristic of hairy cell leukemia (HCL) and is dependent upon activation of proto-oncogenes Ras and JunD. Proteins and DNA elements that influence transcription of Integrin ?X include Sp1 and Sp1-like factors, AP-1 family, C/EBP, Oct-2 and PU.1. Integrin ?X is present on monocyte derivative dendritic cells (DCs), macrophages and NK cells. Upon activation, DCs present in skin (Langerhans cells), lining of nose, lung, stomach, intestine and blood can migrate to lymphoid tissues and interact with T and B cells to initiate and shape the immune response. |
Conjucates | Unconjugated |
Immunogen | Peptide |
Uniprot ID |
Molecular Weight | Theoretical: 145 kDa. |
Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. |
Transport | Shipping with blue ice. |
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