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SGK1-IN-1

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Catalog No. T12890Cas No. 1279829-87-6

SGK1-IN-1 (compound 14n) is a highly potent SGK1 (Serum/Glucocorticoid Regulated Kinase 1) inhibitor, with inhibitory activities of 41 nm, 128 nm, and 310 nm against hSGK1/2/3 at 500 μM ATP, respectively, and can be used for studying SGK1-related cancers and metabolic diseases.

SGK1-IN-1

SGK1-IN-1

😃Good
Catalog No. T12890Cas No. 1279829-87-6
SGK1-IN-1 (compound 14n) is a highly potent SGK1 (Serum/Glucocorticoid Regulated Kinase 1) inhibitor, with inhibitory activities of 41 nm, 128 nm, and 310 nm against hSGK1/2/3 at 500 μM ATP, respectively, and can be used for studying SGK1-related cancers and metabolic diseases.
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1 mg$149-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
SGK1-IN-1 (compound 14n) is a highly potent SGK1 (Serum/Glucocorticoid Regulated Kinase 1) inhibitor, with inhibitory activities of 41 nm, 128 nm, and 310 nm against hSGK1/2/3 at 500 μM ATP, respectively, and can be used for studying SGK1-related cancers and metabolic diseases.
Targets&IC50
SGK1:1 nM
In vitro
Method:
Kinase inhibition assays were conducted to evaluate the selectivity and activity of SGK1-IN-1 (14n) against SGK family members at different ATP concentrations. Additionally, its inhibitory effect on GSK3β phosphorylation was assessed in U2OS cells.

Result:
SGK1-IN-1 showed strong activity against hSGK1 (IC₅₀ = 1 nM), good activity against hSGK2, moderate activity against hSGK3 (IC₅₀ = 41 nM), and exhibited cellular activity with an IC₅₀ of 0.69 μM in U2OS cells.[1]
Chemical Properties
Molecular Weight418.83
FormulaC17H12ClFN6O2S
Cas No.1279829-87-6
SmilesO=S(=O)(NC=1C=CC(=CC1)C2=NC=3NN=C(N)C3N=C2)C4=CC(Cl)=CC=C4F
Relative Density.1.646 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 1.5 mg/mL (3.58 mM), when pH is adjusted to 12 with 1M NaOH.
DMSO: 40 mg/mL (95.5 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Saline: 2 mg/mL (4.78 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.3876 mL11.9380 mL23.8760 mL119.3802 mL
DMSO
1mg5mg10mg50mg
5 mM0.4775 mL2.3876 mL4.7752 mL23.8760 mL
10 mM0.2388 mL1.1938 mL2.3876 mL11.9380 mL
20 mM0.1194 mL0.5969 mL1.1938 mL5.9690 mL
50 mM0.0478 mL0.2388 mL0.4775 mL2.3876 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SGK1-IN-1SGK-1-IN-1SGK1IN1SGK1 IN 1SGK-1
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