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Catalog No. T74698Cas No. 2765081-21-6
RMC-6236 is a RAS(ON)MULTI inhibitor with anticancer activity and is used in the study of advanced malignant solid tumors and colorectal cancer.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$297In Stock
5 mg$786In Stock
10 mg$1,180In Stock
25 mg$1,980In Stock
50 mg$2,890In Stock
100 mg$4,130In Stock
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Product Introduction

RMC-6236 is a RAS(ON)MULTI inhibitor with anticancer activity and is used in the study of advanced malignant solid tumors and colorectal cancer.
In vitro
METHODS: HPAC and Capan-2 cell lines were treated with RMC-6236 (1, 3, 10, 30nM, 4h), and time and concentration-dependent changes in RAS pathway signaling markers pERK, pAKT and pS6 were observed.
RESULTS: Time- and concentration-dependent inhibition of RAS pathway signaling markers pERK, pAKT, and pS6 was observed, with sustained inhibition of pERK and pS6 in Capan-2 cells up to at least 48 h. HPAC cells also exhibited sustained pERK inhibition and time-dependent induction of apoptosis.[2]
In vivo
METHODS: Capan-2 (KRASG12V/WT, PDAC) and NCI-H441 (KRASG12V/WT, NSCLC) xenografted homozygous BALB/c nude mice were treated with RMC-6236 (3, 10, or 25 mg/kg, orally once a day), and blood and tumors were collected at indicated time points.
RESULTS: At the 25 mg/kg dose, RMC-6236 was able to maintain more than 80% inhibition of tumor pERK levels within 24 hours of administration; at the 10 mg/kg dose, RMC-6236 caused modest tumor regression in the sensitive model and led to 13% and 29% mean tumor regression in the Capan-2 and NCI-H441 models.[2]
Chemical Properties
Molecular Weight811.05
Cas No.2765081-21-6
Storage & Solubility Information
Storagestore at low temperature|Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 200 mg/mL (246.59 mM), Sonication is recommended.
Solution Preparation Table
1 mM1.2330 mL6.1648 mL12.3297 mL61.6485 mL
5 mM0.2466 mL1.2330 mL2.4659 mL12.3297 mL
10 mM0.1233 mL0.6165 mL1.2330 mL6.1648 mL
20 mM0.0616 mL0.3082 mL0.6165 mL3.0824 mL
50 mM0.0247 mL0.1233 mL0.2466 mL1.2330 mL
100 mM0.0123 mL0.0616 mL0.1233 mL0.6165 mL


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