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RMC-6236

Catalog No. T74698 CAS 2765081-21-6

Synonyms: RAS-IN-2

RMC-6236（RAS-IN-2) is a potent inhibitor of RAS(ON) MULTI, utilized in cancer research [1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

RMC-6236, CAS 2765081-21-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 810.00
5 mg	In stock	$ 1,980.00
10 mg	In stock	$ 2,970.00
25 mg	In stock	$ 4,620.00
50 mg	In stock	$ 6,230.00

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Biological Description

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Description	RMC-6236（RAS-IN-2) is a potent inhibitor of RAS(ON) MULTI, utilized in cancer research [1].
In vitro	METHODS: HPAC and Capan-2 cell lines were treated with RMC-6236 (1, 3, 10, 30nM, 4h), and time and concentration-dependent changes in RAS pathway signaling markers pERK, pAKT and pS6 were observed. RESULTS: Time- and concentration-dependent inhibition of RAS pathway signaling markers pERK, pAKT, and pS6 was observed, with sustained inhibition of pERK and pS6 in Capan-2 cells up to at least 48 h. HPAC cells also exhibited sustained pERK inhibition and time-dependent induction of apoptosis.[2]
In vivo	METHODS: Capan-2 (KRASG12V/WT, PDAC) and NCI-H441 (KRASG12V/WT, NSCLC) xenografted homozygous BALB/c nude mice were treated with RMC-6236 (3, 10, or 25 mg/kg, orally once a day), and blood and tumors were collected at indicated time points. RESULTS: At the 25 mg/kg dose, RMC-6236 was able to maintain more than 80% inhibition of tumor pERK levels within 24 hours of administration; at the 10 mg/kg dose, RMC-6236 caused modest tumor regression in the sensitive model and led to 13% and 29% mean tumor regression in the Capan-2 and NCI-H441 models.[2]

Synonyms	RAS-IN-2
Molecular Weight	811.05
Formula	C44H58N8O5S
CAS No.	2765081-21-6

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Holderfield M, et al. Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature. 2024 Apr 8. 2. Jiang J, et al. Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers. Cancer Discov. 2024 Apr 9:OF1-OF24.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RMC-6236 2765081-21-6 RAS-IN-2 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.