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RMC-6236

RMC-6236
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Purity:100%
ee:100%
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RMC-6236

Catalog No. T74698Cas No. 2765081-21-6
RMC-6236 is a RAS(ON)MULTI inhibitor with anticancer activity and is used in the study of advanced malignant solid tumors and colorectal cancer.
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Pack SizePriceAvailabilityQuantity
1 mg$297In Stock
5 mg$786In Stock
10 mg$1,180In Stock
25 mg$1,980In Stock
50 mg$2,890In Stock
100 mg$4,130In Stock
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Product Introduction

Bioactivity
Description
RMC-6236 is a RAS(ON)MULTI inhibitor with anticancer activity and is used in the study of advanced malignant solid tumors and colorectal cancer.
In vitro
METHODS: HPAC and Capan-2 cell lines were treated with RMC-6236 (1, 3, 10, 30nM, 4h), and time and concentration-dependent changes in RAS pathway signaling markers pERK, pAKT and pS6 were observed.
RESULTS: Time- and concentration-dependent inhibition of RAS pathway signaling markers pERK, pAKT, and pS6 was observed, with sustained inhibition of pERK and pS6 in Capan-2 cells up to at least 48 h. HPAC cells also exhibited sustained pERK inhibition and time-dependent induction of apoptosis.[2]
In vivo
METHODS: Capan-2 (KRASG12V/WT, PDAC) and NCI-H441 (KRASG12V/WT, NSCLC) xenografted homozygous BALB/c nude mice were treated with RMC-6236 (3, 10, or 25 mg/kg, orally once a day), and blood and tumors were collected at indicated time points.
RESULTS: At the 25 mg/kg dose, RMC-6236 was able to maintain more than 80% inhibition of tumor pERK levels within 24 hours of administration; at the 10 mg/kg dose, RMC-6236 caused modest tumor regression in the sensitive model and led to 13% and 29% mean tumor regression in the Capan-2 and NCI-H441 models.[2]
AliasRMC6236
Chemical Properties
Molecular Weight811.05
FormulaC44H58N8O5S
Cas No.2765081-21-6
Storage & Solubility Information
Storagestore at low temperature|Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 200 mg/mL (246.59 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.2330 mL6.1648 mL12.3297 mL61.6485 mL
5 mM0.2466 mL1.2330 mL2.4659 mL12.3297 mL
10 mM0.1233 mL0.6165 mL1.2330 mL6.1648 mL
20 mM0.0616 mL0.3082 mL0.6165 mL3.0824 mL
50 mM0.0247 mL0.1233 mL0.2466 mL1.2330 mL
100 mM0.0123 mL0.0616 mL0.1233 mL0.6165 mL

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