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Neurotensin(8-13)

Name: Neurotensin(8-13)
Brand: TargetMol
SKU: T7617
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7617Cas No. 60482-95-3

Neurotensin(8-13) is Neurotensin (NT) fragment, Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density.

Neurotensin(8-13)

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Purity: 99.95%

Catalog No. T7617Cas No. 60482-95-3

Neurotensin(8-13) is Neurotensin (NT) fragment, Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$69	-	In Stock

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Purity:99.95%

Appearance:Solid

Color:White

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COA HPLC

Product Introduction

Bioactivity

Description	Neurotensin(8-13) is Neurotensin (NT) fragment, Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density.
In vivo	The internalization of the receptor induced by neurotensin (8-13) leads to a decrease in the density of the NT1 receptor (NTR1) on the cell surface.In ht-29 cells and rat primary cultured neurons, the neurotensin (NT) receptor was down-regulated by high concentrations of extracellular peptides.The representation of cell surface receptors is also different[1]

Chemical Properties

Molecular Weight	816.99
Formula	C₃₈H₆₄N₁₂O₈
Cas No.	60482-95-3
Smiles	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(O)=O
Relative Density.	1.31g/cm3
Sequence	Arg-Arg-Pro-Tyr-Ile-Leu
Sequence Short	RRPYIL

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (61.2 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.2240 mL	6.1200 mL	12.2401 mL	61.2003 mL
5 mM	0.2448 mL	1.2240 mL	2.4480 mL	12.2401 mL
10 mM	0.1224 mL	0.6120 mL	1.2240 mL	6.1200 mL
20 mM	0.0612 mL	0.3060 mL	0.6120 mL	3.0600 mL
50 mM	0.0245 mL	0.1224 mL	0.2448 mL	1.2240 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc