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MK-4074

Name: MK-4074
Brand: TargetMol
SKU: T12062
Rating: 4.5 (1 reviews)

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Catalog No. T12062Cas No. 1039758-22-9

MK-4074 is a liver-specific acetyl-CoA carboxylase (ACC1 and ACC2) inhibitor with an IC50 of 3 nM.

MK-4074

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Catalog No. T12062Cas No. 1039758-22-9

MK-4074 is a liver-specific acetyl-CoA carboxylase (ACC1 and ACC2) inhibitor with an IC50 of 3 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$3,320	3-6 months	3-6 months
50 mg	$4,380	3-6 months	3-6 months
100 mg	$6,100	3-6 months	3-6 months

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	MK-4074 is a liver-specific acetyl-CoA carboxylase (ACC1 and ACC2) inhibitor with an IC50 of 3 nM.
Targets&IC50	ACC1:3 nM
In vitro	MK-4074 is highly liver specific because it is a substrate of organic anion transport protein (OATP) transporters that are present only in hepatocytes, and excretion of MK-4074 from hepatocytes into bile is dependent on the MRP2 efflux transporter[1].
In vivo	MK-4074 orally at 30 mg/kg reduces hepatic DNL by 83%, 70%, and 51% at 4, 8, and 12 hr post-dose, respectively. Single oral doses of MK-4074 at 30 and 100 mg/kg significantly increases plasma total ketones, a surrogate biomarker for hepatic FAO, by 1.5-fold to 3-fold for up to 8 hr[1].

Chemical Properties

Molecular Weight	565.62
Formula	C₃₃H₃₁N₃O₆
Cas No.	1039758-22-9
Smiles	COc1cc(cc2n(cc(C)c12)C1CC1)C(=O)N1CCC2(CC1)CC(=O)c1cc(ccc1O2)-c1cncc(c1)C(O)=O
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.3 mg/mL (147.27 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (5.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7680 mL	8.8399 mL	17.6797 mL	88.3986 mL
5 mM	0.3536 mL	1.7680 mL	3.5359 mL	17.6797 mL
10 mM	0.1768 mL	0.8840 mL	1.7680 mL	8.8399 mL
20 mM	0.0884 mL	0.4420 mL	0.8840 mL	4.4199 mL
50 mM	0.0354 mL	0.1768 mL	0.3536 mL	1.7680 mL
100 mM	0.0177 mL	0.0884 mL	0.1768 mL	0.8840 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MK-4074MK4074MK 4074

MK-4074

MK-4074

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In Vivo Formulation Calculator (Clear solution)

Dose Conversion

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Keywords