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IL-13 Protein, Human, Recombinant (His)

Catalog No. TMPJ-00575
Synonyms: Interleukin-13, IL-13

Interleukin-13 is also known as IL-13. It is a protein that in humans is encoded by the IL13 gene. Interleukin-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells.It is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils.

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IL-13 Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg In stock $ 118.00
50 μg 5 days $ 350.00
500 μg 5 days $ 1,220.00
1 mg 5 days $ 2,970.00
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Biological Description
Technical Params
Product Properties
Biological Information Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED50 for this effect is 1.5-4.5 ng/ml. (QC verified)

Description Interleukin-13 is also known as IL-13. It is a protein that in humans is encoded by the IL13 gene. Interleukin-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells.It is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils.
Species Human
Expression System Human Cells
Tag C-6His
Accession Number AAH96139
Synonyms Interleukin-13, IL-13
Amino Acid Gly35-Asn146
Construction Recombinant Human Interleukin-13 is produced by our Mammalian expression system and the target gene encoding Gly35-Asn146 is expressed with a 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)

Molecular Weight 13-30 KDa, reducing conditions
Endotoxin Less than 10 EU/µg as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.

Research Background Interleukin-13 is also known as IL-13. It is a protein that in humans is encoded by the IL13 gene. Interleukin-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells.It is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils.

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Keywords

IL-13 Protein, Human, Recombinant (His) Interleukin-13 IL-13 IL 13 IL13 recombinant recombinant-proteins proteins protein

 

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