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Anti-human CD274 (B7-H1, PD-L1) Antibody (9X90)

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Catalog No. TMAB-07398

Anti-human CD274 (B7-H1, PD-L1) Antibody (9X90) is a Mouse antibody targeting human CD274 (B7-H1, PD-L1). Anti-human CD274 (B7-H1, PD-L1) Antibody (9X90) can be used in FCM.

Anti-human CD274 (B7-H1, PD-L1) Antibody (9X90)

Anti-human CD274 (B7-H1, PD-L1) Antibody (9X90)

😃Good
Catalog No. TMAB-07398
Anti-human CD274 (B7-H1, PD-L1) Antibody (9X90) is a Mouse antibody targeting human CD274 (B7-H1, PD-L1). Anti-human CD274 (B7-H1, PD-L1) Antibody (9X90) can be used in FCM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
100 μg$3527-10 days7-10 days
200 μg$1,0597-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-human CD274 (B7-H1, PD-L1) Antibody (9X90) is a Mouse antibody targeting human CD274 (B7-H1, PD-L1). Anti-human CD274 (B7-H1, PD-L1) Antibody (9X90) can be used in FCM.
Ig Type
IgG1
Clone
9X90
Reactivity
Human
Application
Recommended Dose
FCM: 1μg/Test
Antibody Type
Monoclonal
Host SpeciesMouse
Subcellular LocalizationIsoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Endomembrane system; Single-pass type I membrane protein.
Tissue SpecificityHighly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
ConstructionHybridoma Monoclonal Antibody
PurificationProtein G purified
AppearanceLiquid
Formulation0.01M PBS (pH7.4).
Research BackgroundThis gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Antigen Details
Gene Name
CD274
Gene ID
Protein Name
Programmed cell death 1 ligand 1
Function
Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
Chemical Properties
Molecular WeightTheoretical: 32 kDa. Actual: 40 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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