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Anti-mouse CD45 Antibody (6A619)
😃Good
Catalog No. TMAB-08954
Anti-mouse CD45 Antibody (6A619) is a Rat antibody targeting mouse CD45. Anti-mouse CD45 Antibody (6A619) can be used in FCM.
Anti-mouse CD45 Antibody (6A619)
Anti-mouse CD45 Antibody (6A619)
😃Good
Catalog No. TMAB-08954
Anti-mouse CD45 Antibody (6A619) is a Rat antibody targeting mouse CD45. Anti-mouse CD45 Antibody (6A619) can be used in FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 μg | $353 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-mouse CD45 Antibody (6A619) is a Rat antibody targeting mouse CD45. Anti-mouse CD45 Antibody (6A619) can be used in FCM. |
| Ig Type | Rat IgG2b, k |
| Clone | 6A619 |
| Reactivity | Mouse |
| Application | |
| Recommended Dose | FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rat |
| Subcellular Localization | Membrane; Single-pass type I membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Research Background | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling |
| Gene Name | PTPRC |
| Gene ID | |
| Protein Name | Receptor-type tyrosine-protein phosphatase C |
| Function | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. |
| Molecular Weight | Theoretical: 143 kDa. Actual: 220 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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