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Zalospirone

Catalog No. T68172 CAS 114298-18-9

Zalospirone is a 5-HT1A receptor agonist that can be used to study anxiety disorders and major depressive disorder.

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Zalospirone, CAS 114298-18-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 350.00
5 mg	In stock	$ 828.00
10 mg	In stock	$ 1,130.00
25 mg	In stock	$ 1,590.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,500.00
500 mg	In stock	$ 4,900.00

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Purity: 100%

Purity: 98.67%

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Description

Zalospirone is a 5-HT1A receptor agonist that can be used to study anxiety disorders and major depressive disorder.

In vivo

We report here the results of an antidepressant trial with zalospirone, a novel cyclic imide with 5-HT1A partial agonist activity. Two hundred eighty-seven outpatients (mean age 44 years, 55% men, 45% nonfertile women) who met the criteria for unipolar major depression with a minimum 21-item Hamilton Rating Scale for Depression (HAM-D) score of 20 were randomly assigned to receive 6 weeks of double-blind treatment with either placebo or one of three fixed doses of zalospirone (6, 15, or 45 mg/day), administered three times daily. The high dose (45 mg) of zalospirone produced a significant antidepressant effect compared with the placebo from week 2 with mean improvement (change from baseline) in HAM-D total score of 12.8 versus 8.4 (p < 0.05) at week 6. Clinical improvement with the high dose of zalospirone was consistent across all outcome measures, however, only in the observed cases and not the last-observation-carried-forward analyses. Improvement with the 6-mg or 15-mg doses was greater than that with placebo, but not significantly so, suggesting a dose-response effect. Although the 45-mg dose of zalospirone seemed to have significant antidepressant efficacy, it was not well tolerated.[1]

Molecular Weight	419.52
Formula	C24H29N5O2
CAS No.	114298-18-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1mg/ml, Sonication is recommended.

References and Literature

1. Rickels K, et al. Zalospirone in major depression: a placebo-controlled multicenter study. J Clin Psychopharmacol. 1996;16(3):212-217. 2. Richards JB, et al. Buspirone, gepirone, ipsapirone, and zalospirone have distinct effects on the differential-reinforcement-of-low-rate 72-s schedule when compared with 5-HTP and diazepam. Psychopharmacology (Berl). 1994;114(1):39-46.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Membrane Protein-targeted Compound Library Bioactive Compounds Library Max Neurotransmitter Receptor Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

VUF 10166 Azacyclonol YM348 Lurasidone Perospirone Ampreloxetine Blonanserin gamma-Mangostin

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Keywords

Zalospirone 114298-18-9 GPCR/G Protein Neuroscience 5-HT Receptor inhibitor inhibit

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