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NOX-6-18

Name: NOX-6-18
Brand: TargetMol
SKU: T83972
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T83972Cas No. 898211-21-7

Alias GPR132-B-160, GPR132 antagonist 1

NOX-6-18 (GPR132-B-160) is a highly potent and selective GPR132 antagonist with insulinotropic activity that modulates macrophage reprogramming in pancreatic islets and reduces weight gain.

NOX-6-18

🥰Excellent

Purity: 99.29%

Catalog No. T83972Alias GPR132-B-160, GPR132 antagonist 1Cas No. 898211-21-7

NOX-6-18 (GPR132-B-160) is a highly potent and selective GPR132 antagonist with insulinotropic activity that modulates macrophage reprogramming in pancreatic islets and reduces weight gain.

Pack Size	Price	Availability
1 mg	$68	In Stock
5 mg	$163	In Stock
10 mg	$238	In Stock
25 mg	$397	In Stock
50 mg	$579	In Stock
100 mg	$786	In Stock
200 mg	$1,080	In Stock
1 mL x 10 mM (in DMSO)	$173	In Stock

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Purity:99.29%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	NOX-6-18 (GPR132-B-160) is a highly potent and selective GPR132 antagonist with insulinotropic activity that modulates macrophage reprogramming in pancreatic islets and reduces weight gain.
Targets&IC50	GPR132:0.075 μM(EC50)
Synonyms	GPR132-B-160, GPR132 antagonist 1

Chemical Properties

Molecular Weight	359.4
Formula	C₁₈H₁₇NO₅S
Cas No.	898211-21-7
Smiles	O=C(O)C=1OC=2C=CC(=CC2C1C)S(=O)(=O)NCCC=3C=CC=CC3
Relative Density.	1.366 g/cm3 at 20℃ (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (222.59 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7824 mL	13.9121 mL	27.8242 mL	139.1208 mL
5 mM	0.5565 mL	2.7824 mL	5.5648 mL	27.8242 mL
10 mM	0.2782 mL	1.3912 mL	2.7824 mL	13.9121 mL
20 mM	0.1391 mL	0.6956 mL	1.3912 mL	6.9560 mL
50 mM	0.0556 mL	0.2782 mL	0.5565 mL	2.7824 mL
100 mM	0.0278 mL	0.1391 mL	0.2782 mL	1.3912 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc