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KIF18A-IN-3

🥰Excellent
Catalog No. T64068Cas No. 2600577-49-7

KIF18A-IN-3 is an efficient KIF18A inhibitor (IC50 = 61nM) that induces mitotic arrest and increases the number of mitotic cells in tumor tissues. It can be used in tumor research.

KIF18A-IN-3

KIF18A-IN-3

🥰Excellent
Purity: 98.45%
Catalog No. T64068Cas No. 2600577-49-7
KIF18A-IN-3 is an efficient KIF18A inhibitor (IC50 = 61nM) that induces mitotic arrest and increases the number of mitotic cells in tumor tissues. It can be used in tumor research.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$196-In Stock
5 mg$490-In Stock
10 mg$718-In Stock
25 mg$1,080-In Stock
1 mL x 10 mM (in DMSO)$595-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:98.45%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
KIF18A-IN-3 is an efficient KIF18A inhibitor (IC50 = 61nM) that induces mitotic arrest and increases the number of mitotic cells in tumor tissues. It can be used in tumor research.
Targets&IC50
KIF18A:61 nM
In vitro
KIF18A-IN-3 is a potent KIF18A inhibitor with IC50 = 61 nM. [1]
In vivo
KIF18A-IN-3 (100 mg/kg, ip.) increased the number of mitotic cells (PH3-positive cells) in CD1 mouse tumor tissue for up to 24 hours. [1]
Chemical Properties
Molecular Weight574.76
FormulaC28H38N4O5S2
Cas No.2600577-49-7
SmilesO=C(NC1=CC=CC(=C1)S(=O)(=O)NC(C)(C)C)C2=CC=C(C=C2N3CCC4(CC3)CC4)NS(=O)(=O)C5(C)CC5
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (139.19 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7399 mL8.6993 mL17.3986 mL86.9928 mL
5 mM0.3480 mL1.7399 mL3.4797 mL17.3986 mL
10 mM0.1740 mL0.8699 mL1.7399 mL8.6993 mL
20 mM0.0870 mL0.4350 mL0.8699 mL4.3496 mL
50 mM0.0348 mL0.1740 mL0.3480 mL1.7399 mL
100 mM0.0174 mL0.0870 mL0.1740 mL0.8699 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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