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Tyr-Gly-Gly-Phe-Met-OH

Name: Tyr-Gly-Gly-Phe-Met-OH
Brand: TargetMol
SKU: T7211
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7211Cas No. 58569-55-4

Alias Methionine enkephalin, Met-Enkephalin

Tyr-Gly-Gly-Phe-Met-OH (Met-Enkephalin) is a naturally occurring endogenous opioid peptide that inhibits tumor growth by binding to the opioid receptor.

Tyr-Gly-Gly-Phe-Met-OH

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Catalog No. T7211Alias Methionine enkephalin, Met-EnkephalinCas No. 58569-55-4

Tyr-Gly-Gly-Phe-Met-OH (Met-Enkephalin) is a naturally occurring endogenous opioid peptide that inhibits tumor growth by binding to the opioid receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$52	In Stock	In Stock
50 mg	$83	In Stock	In Stock
100 mg	$131	-	In Stock
200 mg	$193	-	In Stock
1 mL x 10 mM (in DMSO)	$32	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:≥95%

Appearance:Solid

Color:White

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COA HNMR

Product Introduction

Bioactivity

Description	Tyr-Gly-Gly-Phe-Met-OH (Met-Enkephalin) is a naturally occurring endogenous opioid peptide that inhibits tumor growth by binding to the opioid receptor.
In vitro	Tyr-Gly-Gly-Phe-Met-OH,as know as Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems.?MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells.?Clinical trial studies in cancer patients have shown that MENK activates immune cells directly and by inhibiting regulatory T-cells (Tregs).?MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells.?All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy.?Furthermore, they reveal a relationship between the endocrine and immune systems.
Synonyms	Methionine enkephalin, Met-Enkephalin

Chemical Properties

Molecular Weight	573.66
Formula	C₂₇H₃₅N₅O₇S
Cas No.	58569-55-4
Smiles	CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O
Relative Density.	1.324 g/cm3
Sequence	Tyr-Gly-Gly-Phe-Met
Sequence Short	YGGFM

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 81.67 mg/mL (142.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7432 mL	8.7160 mL	17.4319 mL	87.1596 mL
5 mM	0.3486 mL	1.7432 mL	3.4864 mL	17.4319 mL
10 mM	0.1743 mL	0.8716 mL	1.7432 mL	8.7160 mL
20 mM	0.0872 mL	0.4358 mL	0.8716 mL	4.3580 mL
50 mM	0.0349 mL	0.1743 mL	0.3486 mL	1.7432 mL
100 mM	0.0174 mL	0.0872 mL	0.1743 mL	0.8716 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc